A0A3D8YL31 · A0A3D8YL31_STAPS

Function

function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit.

Pathway

Carbohydrate biosynthesis; Calvin cycle.
Carbohydrate degradation; pentose phosphate pathway.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site28substrate
Site28Important for catalytic activity
Binding site260substrate
Site260Important for catalytic activity
Binding site355substrate
Binding site382substrate
Binding site459substrate
Binding site467substrate
Binding site471substrate
Binding site518substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functiontransketolase activity
Biological ProcessDNA recombination
Biological Processpentose-phosphate shunt
Biological Processreductive pentose-phosphate cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transketolase
  • EC number

Gene names

    • Name
      tkt
    • ORF names
      DV961_10300

Organism names

  • Taxonomic identifier
  • Strain
    • ST496-2
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus > Staphylococcus intermedius group

Accessions

  • Primary accession
    A0A3D8YL31

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain352-523Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the transketolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    661
  • Mass (Da)
    72,238
  • Last updated
    2019-01-16 v1
  • Checksum
    A8AE09A8A97ED514
MSQRNDSLAINTIRGLSIDAIEKANSGHPGLPMGAAPMAYTLWTRHLNFNPKSHEYFNRDRFILSAGHGSALLYSLLHVSGSLELDELKQFRQWDSKTPGHPEYHHTQGVEITTGPLGQGFAMSVGMAMAEKHLAAKFNKDIDVVDHYTYVLASDGDLMEGISHEAASLAGHLKLDKLITLYDSNDISLDGEASKAFSEDIKKRFEAYGWNHILVKDGNDIEAIDKAIEEAKGQAGPTIIEVKTIIGYGSPNKSNSNASHGAPLGEEERNLTFESYNLDPSKHFHVEDEVYDIFNSTMIQRADENEKAWKEKVEQYAEKYPELYKEFEDAMAGKLPEGYDNELPKFELGHKGASRADSGDVIQALSKAVPTLFGGSADLASSNKSNVKNETDFSAENGVGKNVWFGVREFAMAAAVNGMAAHGGLHPYGATFFVFSDYLKPALRLAAIMGLRSTFVFTHDSIAVGEDGPTHEPIEQLAGLRAIPNLNVIRPADGNETRVAWKVAVESNGTPTALVLTRQGLPVLDVEESTVEEGVRKGAYVVFETEKSPEYVLLASGSEVSLTVDVAKALEEQGKGVRVISMPNWNAFENQSKAYQDEILLPHVEKRAAVEMAASLGWHKYVGMNGVVVGIDRYGASAPGDLVVEKYGFTKDNVLAEIEKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QQPC01000071
EMBL· GenBank· DDBJ
REA80662.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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