A0A3D0Q5U4 · A0A3D0Q5U4_ALTSX
- ProteinDNA polymerase III subunit epsilon
- GenednaQ
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids200 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
Cofactor
Protein has several cofactor binding sites:
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 3'-5' exonuclease activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA-directed DNA polymerase activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA replication proofreading |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA polymerase III subunit epsilon
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Alteromonadaceae > Alteromonas/Salinimonas group > Alteromonas
Accessions
- Primary accessionA0A3D0Q5U4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-176 | Exonuclease | ||||
Sequence: RQIVLDTETTGINPKEGHRIIEIGCVEVINRRLTGNHFHVYINPKREIEQEAIEVHGITNEFLADKPVFADVAGEFIEFIRGGQLVIHNAPFDVGFMDHEFAMHGPTASVKTKEICGVLDTLVLARDMHPGQKNNLDALCKRYGIDNSHRELHGALLDAEILADVYLMMTGGQTD |
Family and domain databases
Sequence
- Sequence statusFragment
- Length200
- Mass (Da)22,148
- Last updated2019-01-16 v1
- ChecksumEB6B01EF097A1BA6
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 200 | |||||
Sequence: G |