A0A3B9NXZ1 · A0A3B9NXZ1_9PROT

  • Protein
    Phosphoribosyl-AMP cyclohydrolase
  • Gene
    hisI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site78Mg2+ (UniProtKB | ChEBI)
Binding site79Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site80Mg2+ (UniProtKB | ChEBI)
Binding site82Mg2+ (UniProtKB | ChEBI)
Binding site96Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site103Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH

Gene names

    • Name
      hisI
    • ORF names
      DCK83_04255

Organism names

  • Taxonomic identifier
  • Strain
    • UBA12482
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Nitrosomonadales > Gallionellaceae

Accessions

  • Primary accession
    A0A3B9NXZ1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain31-105Phosphoribosyl-AMP cyclohydrolase

Sequence similarities

Belongs to the PRA-CH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    129
  • Mass (Da)
    14,550
  • Last updated
    2019-01-16 v1
  • MD5 Checksum
    CC655A4F5F4F069309C49A96EDA69626
MSDAWLNKVNWSADGLVPAIAQDAATGRVLMVAWMDREALKRTVETGEAIYWSRSRKKLWHKGEESGHTQKVKEIRIDCDADVVLLQVEQSGGIACHTGRESCFYSKLENGEWVAIDAVLKNPDEIYKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DMCN01000040
EMBL· GenBank· DDBJ
HAF44162.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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