A0A3B8R641 · A0A3B8R641_9BURK

  • Protein
    NADH-quinone oxidoreductase subunit I
  • Gene
    nuoI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site69[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site72[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site75[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site79[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site108[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site111[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site114[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site118[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane respiratory chain complex I
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioniron ion binding
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding
Biological Processaerobic respiration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit I
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit I
    • NDH-1 subunit I

Gene names

    • Name
      nuoI
    • ORF names
      DCE31_00035

Organism names

  • Taxonomic identifier
  • Organism
    Lautropia sp
  • Strain
    • UBA9289
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Lautropia

Accessions

  • Primary accession
    A0A3B8R641

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain59-894Fe-4S ferredoxin-type
Domain99-1284Fe-4S ferredoxin-type

Sequence similarities

Belongs to the complex I 23 kDa subunit family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    168
  • Mass (Da)
    19,227
  • Last updated
    2019-01-16 v1
  • Checksum
    13C16AD9F1404B1A
MASTSPTQAVKDFFQSFMLIELLKGLRLTGKYLFSKKITILYPEEKTPMSPRFRGLHALRRYPNGEERCIACKLCEAVCPAMAITIESQQREDGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETQIHEYHGEKRGDLYFTKEMLLAVGDRYEQEIASARGADAAYR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DLWF01000002
EMBL· GenBank· DDBJ
HAB46716.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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