A0A3B6VMN4 · A0A3B6VMN4_BRAPL

Function

function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site17substrate
Binding site39substrate
Binding site66-75substrate
Active site68Proton donor
Binding site125substrate
Binding site187substrate
Binding site196substrate
Binding site216substrate
Binding site217substrate
Binding site3385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site3425-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site3445-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site364-3725-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site368orotate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmagnesium ion binding
Molecular Functionorotate phosphoribosyltransferase activity
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Orotidine 5'-phosphate decarboxylase
  • EC number
  • Alternative names
    • OMP decarboxylase
      (OMPDCase
      ; OMPdecase
      )
  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT
    ; OPRTase

Gene names

    • Name
      pyrE
    • Synonyms
      pyrF
    • ORF names
      BPP43_09705

Organism names

Accessions

  • Primary accession
    A0A3B6VMN4

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-232Orotidine 5'-phosphate decarboxylase

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.
In the C-terminal section; belongs to the OMP decarboxylase family.
In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    451
  • Mass (Da)
    50,498
  • Last updated
    2018-12-05 v1
  • Checksum
    93F9D740F5FC5D5C
MIIADNNPKDRLIVALDFNSMSEAVALIDELGDEAVFYKVGLELFLYTKGEIIEYLANKNKKVFLDLKFHDIPNTTAMASLFAAKQNVFMFNVHTSGGKKMMEKTVEEIKKLNKENLIIGVTVLTSLSENDIKNMFTSSIALKDLAVNWAKLGKEAGLDGVVCSPKEAAIIKKECGERFRTVCPGVRPKWASVDDQERIMTPKEAIENGCDYLVVGRPITRSEDRVKACRMIVEEIAEGMEHNKKSKAQKIAMALLSSQAVKLNVKEPFTFVSGIKSPIYCDNRYVIGFPEYRKVIVESFVNILKLKDFDIVAGTATAGIPWASFIAYELDKPMCYIRAEKKEHGRGRQIEGADCNGKRLILIEDLISTGGSSIKAFEAAKAEGAIGLEIISIFSYEFEKAKKNFEEANIKFSSLSNFSSLMEIAKDEKYISEDELKKALEWNKDPENWNV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002873
EMBL· GenBank· DDBJ
AGA67123.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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