A0A3B5B5B0 · A0A3B5B5B0_9TELE

Function

function

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.

Catalytic activity

  • (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
    This reaction proceeds in the forward direction.
  • an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA
    EC:2.3.1.15 (UniProtKB | ENZYME | Rhea)
  • dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.

Pathway

Lipid metabolism.
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.

GO annotations

AspectTerm
Cellular Componentmitochondrial outer membrane
Cellular Componentplasma membrane
Molecular Functionglycerol-3-phosphate O-acyltransferase activity
Molecular Functionsn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity
Biological ProcessCDP-diacylglycerol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate acyltransferase 1, mitochondrial
  • EC number

Gene names

    • Name
      GPAM
    • Synonyms
      gpam

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Pomacentridae > Stegastes

Accessions

  • Primary accession
    A0A3B5B5B0

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion outer membrane
; Multi-pass membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain219-352Phospholipid/glycerol acyltransferase
Region666-698Disordered

Sequence similarities

Belongs to the GPAT/DAPAT family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    827
  • Mass (Da)
    94,049
  • Last updated
    2018-12-05 v1
  • Checksum
    34045B34E610088F
MELSDGLLLQVNNGEQWCNRWKHPNEDSDRSTSPSVLRCVASTWKEGLLNRKRPFVGRCCHSCTPQSWERLFNPSIPSLGLRNVIYINETHTRQRGWLARRLSYVLFVMERDVHKDMFARNVVDNVLNNSRVETAIVKVATDLDAASSQPGQEHKAVSKVKQKARAFLQEMVANISPAFIRLTGWVLLRLFNGFFWSIQIHKGQLEMVKKAATEQNVPMVFLPVHKSHIDYLLITLILFCHNIKAPHIAAGNNLSIPILSTLIRKLGGFFIRRKMEETGDGKKDVLYRSLLHAYTEELLRQQQFLEVYLEGTRSRSGKPSPARAGMLSIVVDTLCTGSIPDVLVVPVGISYDRIIEGNYNSEQLGKPKKNESLWGIACGVFRMLRKNYGCVRVDFNQPFSLKEYLDSQRSRHIPPPVSLEHNLMPTIISAQPDAQLFEGQEEEQMNRELPDDIFRRQLINNLAKHVLFTANKSSAIMSTHIVACLLLYRHRQGVVLSKLVEDFFNMKEEILSRDFDLGFSGNSEDVVMRALHLLGNCVNVTSSANRNGEFTVAPSQTVQALFELNFYSNGLFHVFISDAVIACSILSLQRELAMESESDQQPGGLGSLLLSQERLIRKAASLSHFLINEVAVAPPCQTIYQVFHDAVTRLIQYGVLYVAEEDQEELSPSPTEEPWPKKFSEPLSWRSDEEDEDSDFGEEQRDRYLKVSVSAEHQEFFVFLQRLLSPVLEAYSGAAIFVHSLSQPMAESDYTQRLFRYLLTRTERGVAAYGESATHYLVKNTVRTFKELGVLKERRENKVTTLELSSTFLPQANRNKLLQYILGFTLL

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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