A0A3B4Z9V3 · A0A3B4Z9V3_9TELE

Function

Catalytic activity

  • (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the backward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • Hydrolyzes glycerol monoesters of long-chain fatty acids.
    EC:3.1.1.23 (UniProtKB | ENZYME | Rhea)
  • a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a monoacylglycerol + H2O = a fatty acid + glycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoate
    This reaction proceeds in the forward direction.
  • cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site459

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular Componentlipid droplet
Molecular Functionacylglycerol lipase activity
Molecular Functionhormone-sensitive lipase activity
Biological Processcholesterol metabolic process
Biological Processtriglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hormone-sensitive lipase
  • EC number
  • Alternative names
    • Monoacylglycerol lipase LIPE
    • Retinyl ester hydrolase

Gene names

    • Name
      lipe

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Pomacentridae > Stegastes

Accessions

  • Primary accession
    A0A3B4Z9V3

Proteomes

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Lipid droplet
Membrane, caveola

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-27Disordered
Domain37-348Hormone-sensitive lipase N-terminal
Domain381-533Alpha/beta hydrolase fold-3
Region661-681Disordered
Domain709-772Alpha/beta hydrolase fold-3
Region796-833Disordered
Compositional bias800-816Basic and acidic residues

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    867
  • Mass (Da)
    93,703
  • Last updated
    2018-12-05 v1
  • Checksum
    CFF24F339DC36EFB
MASGKKGGVNNRLEKGVNGRRSSKHKEGPVVMDTKAVFAALYSVCEENAAFFSGGAKGSQGDAARRLVEAVNVIQEHARSLEPVITGFAAVYHHFDFDPHIPANGYRSLVKVVRCCLLHIIHKGRYITANRRSIFFRVAHNAGEMEAYCNALCQLRALLYLAQRMLHDNSHGNLFFQDESGLSESFVREYASMHKGCFYGRCLGFQFTPAIRPCLQTIAIGLVAFGENYKRHQSGIGVAASSLFNSGKYAIDPELRGAEFDRITQNLDVHFWKTFWNITETEVLSGLASMTSTQVKVNRALSVPSVPFDLPLAANHRASVTISPPSAHIGTAPVQMRLISYDLREGQDSETLLSLSRSEGGAISLSLGLKTKRLPSSPCLLIHFHGGGFVAQTSKSHEPYLKSWSQDLGVPILSVDYSLAPEAPFPRALEECFYAYCWALRNHHLLGWTGEKVCLAGDSAGGNLCVTTSMRAAAFGVRMPDGIVAAYPATLLTAYASPSRLLTLMDPLLPLTVLSRCLSAYAGSEPQTEKQVAKVSTLSLVRRDTALMLRDFRQGASNWIQSLLDPNRASASPSTNAELPGATDAVRKSISEASICSPHADPPVPTEPSELLSRKLSVKSQTCQDLGSHNNSVPYSAPLLSERTPEDVSFFLTKDGDTSISSDLSSVAIPPPPAGEDGSELEHRREYPLGFEPLRSEQLAEIRVESSPVVKDPFCSPLLAPDSMLKGLPPIHIVACALDPMLDDSVMFAKRLRNIDQPVTLCVVDDLPHGFLSLSQLSKETREAANVCAERIRAVFTQDTPPEPRKHRKLERTDRGVSAPSGDSGPLFVGPTEGGELAVGRGAKIADGEGSVAVAAQNNTDAGGIGA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A9Y4KCF8A0A9Y4KCF8_9TELElipe846

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias800-816Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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