A0A3B4Z9V3 · A0A3B4Z9V3_9TELE
- ProteinHormone-sensitive lipase
- Genelipe
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids867 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2OThis reaction proceeds in the backward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+This reaction proceeds in the forward direction.
- 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+This reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+This reaction proceeds in the forward direction.
- all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoateThis reaction proceeds in the forward direction.
- cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+This reaction proceeds in the forward direction.
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 459 | |||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | cytosol | |
Cellular Component | lipid droplet | |
Molecular Function | acylglycerol lipase activity | |
Molecular Function | hormone-sensitive lipase activity | |
Biological Process | cholesterol metabolic process | |
Biological Process | triglyceride catabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHormone-sensitive lipase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Pomacentridae > Stegastes
Accessions
- Primary accessionA0A3B4Z9V3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-27 | Disordered | ||||
Sequence: MASGKKGGVNNRLEKGVNGRRSSKHKE | ||||||
Domain | 37-348 | Hormone-sensitive lipase N-terminal | ||||
Sequence: VFAALYSVCEENAAFFSGGAKGSQGDAARRLVEAVNVIQEHARSLEPVITGFAAVYHHFDFDPHIPANGYRSLVKVVRCCLLHIIHKGRYITANRRSIFFRVAHNAGEMEAYCNALCQLRALLYLAQRMLHDNSHGNLFFQDESGLSESFVREYASMHKGCFYGRCLGFQFTPAIRPCLQTIAIGLVAFGENYKRHQSGIGVAASSLFNSGKYAIDPELRGAEFDRITQNLDVHFWKTFWNITETEVLSGLASMTSTQVKVNRALSVPSVPFDLPLAANHRASVTISPPSAHIGTAPVQMRLISYDLREGQD | ||||||
Domain | 381-533 | Alpha/beta hydrolase fold-3 | ||||
Sequence: LIHFHGGGFVAQTSKSHEPYLKSWSQDLGVPILSVDYSLAPEAPFPRALEECFYAYCWALRNHHLLGWTGEKVCLAGDSAGGNLCVTTSMRAAAFGVRMPDGIVAAYPATLLTAYASPSRLLTLMDPLLPLTVLSRCLSAYAGSEPQTEKQVA | ||||||
Region | 661-681 | Disordered | ||||
Sequence: SSDLSSVAIPPPPAGEDGSEL | ||||||
Domain | 709-772 | Alpha/beta hydrolase fold-3 | ||||
Sequence: VVKDPFCSPLLAPDSMLKGLPPIHIVACALDPMLDDSVMFAKRLRNIDQPVTLCVVDDLPHGFL | ||||||
Region | 796-833 | Disordered | ||||
Sequence: FTQDTPPEPRKHRKLERTDRGVSAPSGDSGPLFVGPTE | ||||||
Compositional bias | 800-816 | Basic and acidic residues | ||||
Sequence: TPPEPRKHRKLERTDRG |
Sequence similarities
Belongs to the 'GDXG' lipolytic enzyme family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length867
- Mass (Da)93,703
- Last updated2018-12-05 v1
- ChecksumCFF24F339DC36EFB
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A9Y4KCF8 | A0A9Y4KCF8_9TELE | lipe | 846 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 800-816 | Basic and acidic residues | ||||
Sequence: TPPEPRKHRKLERTDRG |
Keywords
- Technical term