A0A3B4EYJ6 · A0A3B4EYJ6_9CICH

  • Protein
    Choline/ethanolaminephosphotransferase 1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.

Catalytic activity

  • 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
    EC:2.7.8.22 (UniProtKB | ENZYME | Rhea)
  • 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
    EC:2.7.8.2 (UniProtKB | ENZYME | Rhea)
  • 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H+
    This reaction proceeds in the forward direction.
    EC:2.7.8.2 (UniProtKB | ENZYME | Rhea)
  • a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H+
    This reaction proceeds in the forward direction.
    EC:2.7.8.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi apparatus
Cellular Componentnuclear membrane
Molecular Functiondiacylglycerol cholinephosphotransferase activity
Molecular Functionethanolaminephosphotransferase activity
Biological Processphosphatidylethanolamine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Choline/ethanolaminephosphotransferase 1
  • EC number
  • Alternative names
    • 1-alkenyl-2-acylglycerol choline phosphotransferase

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Haplochromini > Pundamilia

Accessions

  • Primary accession
    A0A3B4EYJ6

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Nucleus membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane91-113Helical
Transmembrane125-144Helical
Transmembrane190-207Helical
Transmembrane257-275Helical
Transmembrane295-313Helical
Transmembrane325-345Helical
Transmembrane380-398Helical

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-26Disordered

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    426
  • Mass (Da)
    47,272
  • Last updated
    2018-12-05 v1
  • Checksum
    00A145C738BB8466
MSATGQQQGGGLRTRRGLSRDKDPGHGMGMEATCWLSPGVLRRLIELPSPPLSRHQLKRLEEHRYSSAGRSLLEPLMQRYWEWLIGRVPSWIAPNLITIIGLATNVFTTLVLVYYCPTATEQAPLWAYLLCAVGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTSIAAQLGTNPDWMFFCCFAGMFMFYCAHWQTYVSGTLRFGIFDITEVQLCLAGLQMLTATVGPCLWNVMIPILNIQMKMIPAICTLLGAIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPVLHIGSVIILAMMIYKKSAVQLFENHPCLYILAFGFVSAKITNKLVVAHMTKSEMHLHDLAFLGPGLLFLDQYFNSFIDEYLVLWIALILSLFDLVRYCVSVCNQIACHLHIFVFKIKPCSVLGSAPH

Genome annotation databases

Similar Proteins

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