A0A3B3TD72 · A0A3B3TD72_9TELE
- ProteinRAF proto-oncogene serine/threonine-protein kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids600 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]This reaction proceeds in the forward direction.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | Ras protein signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRAF proto-oncogene serine/threonine-protein kinase
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Osteoglossocephala > Osteoglossomorpha > Osteoglossiformes > Mormyridae > Paramormyrops
Accessions
- Primary accessionA0A3B3TD72
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 55-130 | RBD | ||||
Sequence: STIRVYLPNKQRTVVNVRPGMTLHSCLIKALVVRGLQPQCCAVFKLHPGQRSKKSRMDWNTDSTTLIGEELLVEVL | ||||||
Domain | 137-183 | Phorbol-ester/DAG-type | ||||
Sequence: THNFVRKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMC | ||||||
Region | 280-320 | Disordered | ||||
Sequence: YESGSPQSHSPTGWSQSKTPAPTHREKSHSSSMQEKHRIRP | ||||||
Compositional bias | 282-300 | Polar residues | ||||
Sequence: SGSPQSHSPTGWSQSKTPA | ||||||
Compositional bias | 301-320 | Basic and acidic residues | ||||
Sequence: PTHREKSHSSSMQEKHRIRP | ||||||
Domain | 337-600 | Protein kinase | ||||
Sequence: VVLLSRIGSGSFGTVYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMAKDSLAIVAQWCEGSSLFKHLHVQETNFKMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPSGSILWMAPEVIRMQDNNPYSFQSDVYSYGIVLFELMAGDLPYSHIANRDQVILGTISGTCVGPTITTIIIACFPPQHSHCKYLQSCSLISSPLSTGLYFGFCFGGL |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length600
- Mass (Da)67,085
- Last updated2018-12-05 v1
- ChecksumB6B7FA9BCCE487C1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 282-300 | Polar residues | ||||
Sequence: SGSPQSHSPTGWSQSKTPA | ||||||
Compositional bias | 301-320 | Basic and acidic residues | ||||
Sequence: PTHREKSHSSSMQEKHRIRP |