A0A3B3IT25 · A0A3B3IT25_HUMAN
- Protein[histone H3]-trimethyl-L-lysine(4) demethylase
- GeneKDM5B
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1517 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- 3 2-oxoglutarate + N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl4-[histone H3] + 3 succinate
3 CHEBI:16810 + RHEA-COMP:15537 CHEBI:61961 Position: 4+ 3 CHEBI:15379 = 3 CHEBI:16526 + 3 CHEBI:16842 + RHEA-COMP:15547 + 3 CHEBI:30031
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Molecular Function | DNA binding | |
Molecular Function | histone H3K4me/H3K4me2/H3K4me3 demethylase activity | |
Molecular Function | metal ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name[histone H3]-trimethyl-L-lysine(4) demethylase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A3B3IT25
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,425 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 986 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1312 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1314 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1328 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1383 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1384 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1456 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 32-73 | JmjN | ||||
Sequence: CPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPP | ||||||
Domain | 97-187 | ARID | ||||
Sequence: TRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLS | ||||||
Region | 201-230 | Disordered | ||||
Sequence: TDTKDKEYKPHDIPQRQSVQPSETCPPARR | ||||||
Domain | 309-359 | PHD-type | ||||
Sequence: LYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQ | ||||||
Domain | 453-619 | JmjC | ||||
Sequence: EYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYR | ||||||
Domain | 1176-1224 | PHD-type | ||||
Sequence: IKICLCQKAPAAPMIQCELCRDAFHTSCVAVPSISQGLRIWLCPHCRRS | ||||||
Compositional bias | 1374-1390 | Polar residues | ||||
Sequence: PSPAQQTDRSSPVRPSS | ||||||
Region | 1374-1400 | Disordered | ||||
Sequence: PSPAQQTDRSSPVRPSSEKNDCCRGKR | ||||||
Region | 1461-1485 | Disordered | ||||
Sequence: RSAETHSLPSDTSYSEQEDSEDEDA |
Sequence similarities
Belongs to the JARID1 histone demethylase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,517
- Mass (Da)172,514
- Last updated2018-12-05 v1
- Checksum924ECF9167BC8517
Computationally mapped potential isoform sequences
There are 17 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9UGL1 | KDM5B_HUMAN | KDM5B | 1544 | ||
R4GN45 | R4GN45_HUMAN | KDM5B | 77 | ||
A0A3B3IS31 | A0A3B3IS31_HUMAN | KDM5B | 215 | ||
A0A3B3IS40 | A0A3B3IS40_HUMAN | KDM5B | 1539 | ||
A0A3B3ISK2 | A0A3B3ISK2_HUMAN | KDM5B | 189 | ||
A0A3B3ISE6 | A0A3B3ISE6_HUMAN | KDM5B | 1472 | ||
A0A3B3ITA8 | A0A3B3ITA8_HUMAN | KDM5B | 1499 | ||
A0A3B3ITA9 | A0A3B3ITA9_HUMAN | KDM5B | 336 | ||
A0A3B3IT51 | A0A3B3IT51_HUMAN | KDM5B | 297 | ||
A0A3B3IT85 | A0A3B3IT85_HUMAN | KDM5B | 316 | ||
A0A3B3ITN3 | A0A3B3ITN3_HUMAN | KDM5B | 30 | ||
A0A3B3ITR1 | A0A3B3ITR1_HUMAN | KDM5B | 229 | ||
A0A3B3ITR3 | A0A3B3ITR3_HUMAN | KDM5B | 142 | ||
A0A3B3ITE7 | A0A3B3ITE7_HUMAN | KDM5B | 1505 | ||
A0A3B3ITJ3 | A0A3B3ITJ3_HUMAN | KDM5B | 145 | ||
A0A3B3ITJ7 | A0A3B3ITJ7_HUMAN | KDM5B | 1503 | ||
B3KV94 | B3KV94_HUMAN | KDM5B | 1275 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1374-1390 | Polar residues | ||||
Sequence: PSPAQQTDRSSPVRPSS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC098934 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC104463 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |