A0A3B3IRL0 · A0A3B3IRL0_HUMAN

  • Protein
    Serum/glucocorticoid regulated kinase 2
  • Gene
    SGK2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    1/5

Variants

115820406080100120140
GAVLISTCMDNEQRKHFYWPd*GAVLISTCMDNEQRKHFYWPd*
Variant
ID(s)
Position(s)ChangeDescriptionClinical
significance
Provenance
COSV58314204
rs778281277
3S>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
ExAC
dbSNP
gnomAD
COSV58315541
rs1476667216
3S>P
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
dbSNP
gnomAD
rs7718806996A>GExAC
gnomAD
rs14131710446A>SgnomAD
rs19797297517G>VTOPMed
rs21455336958T>SEnsembl
rs37600398310S>CESP
ExAC
TOPMed
gnomAD
rs143363165212Q>*gnomAD
rs151094343
COSV107441383
12Q>HESP
ExAC
TOPMed
gnomAD
cosmic curated
rs197977714113P>LEnsembl
rs197977680913P>STOPMed
rs197977786915R>GEnsembl
rs105180953717N>STOPMed
rs197977847218G>REnsembl
rs105001177521N>ITOPMed
gnomAD
rs105001177521N>STOPMed
gnomAD
rs147249692323G>EgnomAD
rs20000500724P>SVariant of uncertain significance (Ensembl)1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs20000500724P>TVariant of uncertain significance (Ensembl)1000Genomes
ESP
ExAC
TOPMed
gnomAD
COSV58313443
rs1436070727
rs1436070727,COSV58313443
25S>L
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
TOPMed
dbSNP
gnomAD
rs14102914728P>LVariant of uncertain significance (Ensembl)ESP
ExAC
TOPMed
gnomAD
rs138802243129N>DgnomAD
rs197981898029N>KTOPMed
rs126420708430A>VgnomAD
COSV58314787
rs769566731
31Q>*cosmic curated
ExAC
TOPMed
gnomAD
rs214553619231Q>REnsembl
COSV107441381
rs140303557
33T>M
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
cosmic curated
1000Genomes
ExAC
TOPMed
dbSNP
gnomAD
rs77121003934D>NExAC
gnomAD
rs77438401835F>CExAC
gnomAD
rs76108824336D>EExAC
gnomAD
rs36811008136D>GESP
ExAC
TOPMed
gnomAD
COSV100414515
rs200530019
36D>Ncosmic curated
ESP
ExAC
TOPMed
gnomAD
rs36811008136D>VESP
ExAC
TOPMed
gnomAD
COSV58314314
rs200530019
36D>Ycosmic curated
ESP
ExAC
TOPMed
gnomAD
COSV106489132
rs2145536241
38L>Fcosmic curated
Ensembl
rs197982228440V>FTOPMed
rs36982444541I>NESP
TOPMed
gnomAD
rs98763251042G>RgnomAD
rs98763251042G>SgnomAD
rs75420952943K>R
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
ExAC
TOPMed
dbSNP
gnomAD
rs76268636645N>KExAC
gnomAD
rs117217265345N>SgnomAD
rs197982498547G>ETOPMed
rs53547104347G>R1000Genomes
ExAC
TOPMed
gnomAD
rs37278253049V>IESP
TOPMed
rs133907202251L>QgnomAD
COSV58313899
rs752217367
53K>Tcosmic curated
ExAC
TOPMed
gnomAD
rs75604801754R>CExAC
TOPMed
gnomAD
COSV58313398
rs147953497
54R>H
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
cosmic curated
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs14795349754R>L1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs160098895856S>PEnsembl
rs75379461457D>GExAC
gnomAD
rs197983963357D>NEnsembl
rs75379461457D>VExAC
gnomAD
COSV58313159
rs1200346658
59A>V
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
dbSNP
gnomAD
rs14703592661Y>C1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs197984086361Y>HTOPMed
rs14703592661Y>S1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs197984140462A>VTOPMed
rs126757687463V>ATOPMed
gnomAD
COSV107441385
rs746029910
63V>Mcosmic curated
ExAC
TOPMed
gnomAD
rs134592541864K>NgnomAD
TCGA novel
rs1979842824
65V>A
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
TOPMed
gnomAD
rs75867502665V>LExAC
gnomAD
rs121801942768K>ETOPMed
gnomAD
rs136779070368K>RgnomAD
rs197984381369K>NEnsembl
rs26760594270S>FTOPMed
rs197984401370S>PTOPMed
rs78017406071I>VExAC
TOPMed
gnomAD
rs818332876E>GTOPMed
gnomAD
rs818332876E>VTOPMed
gnomAD
rs78143813478S>IExAC
TOPMed
gnomAD
rs78143813478S>NExAC
TOPMed
gnomAD
rs120682713379H>QgnomAD
rs197995682480I>FTOPMed
rs77049190481M>LExAC
TOPMed
gnomAD
rs77049190481M>VExAC
TOPMed
gnomAD
rs74972074782A>PExAC
TOPMed
gnomAD
rs74972074782A>SExAC
TOPMed
gnomAD
COSV100414595
COSV100414657
rs763850331
84R>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
ExAC
TOPMed
dbSNP
gnomAD
COSV107441387
rs569319046
84R>Hcosmic curated
ExAC
TOPMed
gnomAD
COSV100414595
COSV100414657
rs763850331
84R>S
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
ExAC
TOPMed
dbSNP
gnomAD
rs140796665587L>PTOPMed
gnomAD
rs76172670991V>MExAC
gnomAD
rs76261871192R>Q
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
ExAC
TOPMed
dbSNP
gnomAD
COSV58312566
rs750192641
92R>W
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
ExAC
dbSNP
gnomAD
rs197996002794P>LTOPMed
COSV58313311
rs1415736322
96L>Fcosmic curated
TOPMed
gnomAD
rs14916851397V>L1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs14916851397V>M
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
COSV58314483
rs1304306746
100R>Ccosmic curated
gnomAD
COSV58314126
rs367993196
100R>Hcosmic curated
1000Genomes
ESP
ExAC
gnomAD
rs1363763474101Y>CTOPMed
gnomAD
rs778374321104Q>*ExAC
gnomAD
rs1323071785104Q>HgnomAD
rs1979962374105T>AgnomAD
rs1979962374105T>SgnomAD
rs771132667106P>AExAC
gnomAD
COSV107441384
rs377612011
106P>Hcosmic curated
ExAC
TOPMed
gnomAD
rs377612011106P>LExAC
TOPMed
gnomAD
rs377612011106P>RExAC
TOPMed
gnomAD
rs1240899725107E>ATOPMed
gnomAD
rs746625692107E>KExAC
TOPMed
gnomAD
rs1466884509108K>*Ensembl
rs938843585108K>NTOPMed
rs1979964520109L>FTOPMed
rs1187488873110Y>DgnomAD
COSV58313765
rs776084733
112V>M
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
ExAC
TOPMed
dbSNP
gnomAD
rs1399643390114D>GgnomAD
COSV58315103
rs369045712
114D>Ncosmic curated
ExAC
TOPMed
gnomAD
rs369045712114D>YExAC
TOPMed
gnomAD
COSV106489131
rs894730265
115Y>Ccosmic curated
TOPMed
gnomAD
rs894730265115Y>STOPMed
gnomAD
rs1568664724116V>IEnsembl
rs773071898117N>DExAC
TOPMed
gnomAD
rs143273559117N>KESP
ExAC
TOPMed
gnomAD
COSV100414519
rs372059009
118G>R
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
cosmic curated
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs767901983118G>VExAC
gnomAD
rs372059009118G>WESP
ExAC
TOPMed
gnomAD
rs752991711119G>*ExAC
TOPMed
gnomAD
rs756221883119G>VExAC
gnomAD
rs778005111120E>KExAC
gnomAD
rs1395594924121L>HgnomAD
rs1600991607124H>PEnsembl
rs1327166599125L>PgnomAD
COSV58314420
RCV001543614
rs35187177
127R>Q
Colorectal cancer (ClinVar)
Likely pathogenic (Ensembl, ClinVar)cosmic curated
ClinVar
ExAC
TOPMed
dbSNP
gnomAD
rs777117678127R>WExAC
TOPMed
gnomAD
rs1980038865128E>GEnsembl
rs1357905242128E>KgnomAD
COSV58312148
rs915237238
129R>Ccosmic curated
TOPMed
gnomAD
rs915237238129R>GTOPMed
gnomAD
COSV58313047
rs559824768
129R>H
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
ExAC
TOPMed
dbSNP
gnomAD
rs570263979130R>Q1000Genomes
ExAC
TOPMed
gnomAD
rs148253360130R>WESP
ExAC
TOPMed
gnomAD
rs775481466134P>AExAC
TOPMed
gnomAD
rs760973578134P>RExAC
gnomAD
rs775481466134P>TExAC
TOPMed
gnomAD
rs141249005135R>GESP
ExAC
TOPMed
gnomAD
rs199504693135R>QESP
ExAC
TOPMed
gnomAD
rs141249005135R>WESP
ExAC
TOPMed
gnomAD
rs56229314137R>S1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1600991701137R>TEnsembl
rs1980043440139Y>CTOPMed
COSV100414786
rs552024157
140A>T
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
1000Genomes
ExAC
TOPMed
dbSNP
gnomAD
rs1980043957141A>VTOPMed
COSV58313188
rs1460299750
142E>K
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
dbSNP
gnomAD
rs1166299206143V>MgnomAD
rs138125315144A>GESP
TOPMed
gnomAD
rs138125315144A>VESP
TOPMed
gnomAD
rs755742423145S>CExAC
gnomAD
rs755742423145S>RExAC
gnomAD
rs756719391146A>DExAC
gnomAD
rs766451038146A>TExAC
TOPMed
gnomAD
rs1980047251147I>TEnsembl
rs745787170149Y>*ExAC
gnomAD
rs778297714149Y>CExAC
gnomAD
rs1600991758150L>PEnsembl
rs1225705735150L>VTOPMed
gnomAD
rs1252643805151H>RgnomAD
rs886678200155I>FTOPMed
gnomAD
rs779959970155I>NExAC
gnomAD
rs779959970155I>TExAC
gnomAD
rs886678200155I>VTOPMed
gnomAD
rs1980050646158R>GTOPMed
COSV104658103
rs371001587
158R>Kcosmic curated
ESP
ExAC
TOPMed
gnomAD
rs1980051404159*>CTOPMed
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