A0A3B3IEF2 · A0A3B3IEF2_ORYLA
- ProteinHormone-sensitive lipase
- Genelipeb
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids855 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2OThis reaction proceeds in the backward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+This reaction proceeds in the forward direction.
- 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+This reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+This reaction proceeds in the forward direction.
- all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoateThis reaction proceeds in the forward direction.
- cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+This reaction proceeds in the forward direction.
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 459 | |||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | cytosol | |
Cellular Component | lipid droplet | |
Molecular Function | acylglycerol lipase activity | |
Molecular Function | hormone-sensitive lipase activity | |
Biological Process | cholesterol metabolic process | |
Biological Process | triglyceride catabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHormone-sensitive lipase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias
Accessions
- Primary accessionA0A3B3IEF2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-25 | Disordered | ||||
Sequence: MASSKKGGENGKLERGVNGRRSSKL | ||||||
Compositional bias | 8-25 | Basic and acidic residues | ||||
Sequence: GENGKLERGVNGRRSSKL | ||||||
Domain | 37-348 | Hormone-sensitive lipase N-terminal | ||||
Sequence: VFAALYSVCEENATFFSAGGKVSQADSAKRLVESMKLIQEHARSLEPVISGFAAIYHHFDFDPLIPANGYRSLVKVVRCCLLHIIHKGRYIAANRRSIFFRAAHNAGEMEAYCSALCQLRALLYLAQRMLHDNSHGNLFFQDESGLSESFIREYASMHKGCFYGRCLGFQFTPAIRPCLQTIAIGLVAFGENYKRHQSGIGVAASSFFTSGKYAIDPELRGTEFERITQNLDVHFWKTFWNITETEVLSSLASMTSTQVKVNRALSVPPVAFDLPLAANHRASATIAPPSAHIGIAPIQMRLISYDLREGQD | ||||||
Domain | 381-528 | Alpha/beta hydrolase fold-3 | ||||
Sequence: LIHFHGGGFVAQTSKSHEPYLKSWSQDLGVPILSVDYSLAPEAPFPRALEECFYAYCWALRNHHLLGWTGEKVCLAGDSAGGNLCVTTCMRAAAFGVRMPDGVVAAYPATLLTAYASPSRLLTLMDPLLPLSVLSRCLSAYAGSEPQT | ||||||
Compositional bias | 567-597 | Polar residues | ||||
Sequence: NRGSAAPSTAPETPPDTTDTLRKSVSEVSIS | ||||||
Region | 567-612 | Disordered | ||||
Sequence: NRGSAAPSTAPETPPDTTDTLRKSVSEVSISSPHADPPVLPEPAAL | ||||||
Domain | 684-760 | Alpha/beta hydrolase fold-3 | ||||
Sequence: SDQFAEMKLQSSPVFKDPFCSPLLAPDSMLKGLPPIHIVACALDPMLDDSVMFAKRLRSVDQPVTLCVVDDLPHGFL | ||||||
Compositional bias | 788-806 | Basic and acidic residues | ||||
Sequence: TPPEPRKHRKLERTDRGVS | ||||||
Region | 788-855 | Disordered | ||||
Sequence: TPPEPRKHRKLERTDRGVSAPSGERGSLLVGSIEEEEPAVGREAKSAVGEDSVSVTAQNNTDAGGVGA | ||||||
Compositional bias | 838-855 | Polar residues | ||||
Sequence: DSVSVTAQNNTDAGGVGA |
Sequence similarities
Belongs to the 'GDXG' lipolytic enzyme family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length855
- Mass (Da)93,179
- Last updated2018-12-05 v1
- Checksum346BA7FE2DF0D514
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H2MEH2 | H2MEH2_ORYLA | lipeb | 862 | ||
A0A3B3HKY3 | A0A3B3HKY3_ORYLA | lipeb | 691 | ||
A0A3B3IK45 | A0A3B3IK45_ORYLA | lipeb | 743 | ||
A0A3B3II60 | A0A3B3II60_ORYLA | lipeb | 694 | ||
A0A3B3IES8 | A0A3B3IES8_ORYLA | lipeb | 753 | ||
A0A3B3HXB4 | A0A3B3HXB4_ORYLA | lipeb | 695 | ||
A0A3B3I9S6 | A0A3B3I9S6_ORYLA | lipeb | 807 | ||
A0A3B3H8M8 | A0A3B3H8M8_ORYLA | lipeb | 825 | ||
A0A3B3I604 | A0A3B3I604_ORYLA | lipeb | 741 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 8-25 | Basic and acidic residues | ||||
Sequence: GENGKLERGVNGRRSSKL | ||||||
Compositional bias | 567-597 | Polar residues | ||||
Sequence: NRGSAAPSTAPETPPDTTDTLRKSVSEVSIS | ||||||
Compositional bias | 788-806 | Basic and acidic residues | ||||
Sequence: TPPEPRKHRKLERTDRGVS | ||||||
Compositional bias | 838-855 | Polar residues | ||||
Sequence: DSVSVTAQNNTDAGGVGA |
Keywords
- Technical term