A0A3B3HXB4 · A0A3B3HXB4_ORYLA

Function

Catalytic activity

  • (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the backward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • Hydrolyzes glycerol monoesters of long-chain fatty acids.
    EC:3.1.1.23 (UniProtKB | ENZYME | Rhea)
  • a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a monoacylglycerol + H2O = a fatty acid + glycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoate
    This reaction proceeds in the forward direction.
  • cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site428

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular Componentlipid droplet
Molecular Functionacylglycerol lipase activity
Molecular Functionhormone-sensitive lipase activity
Biological Processcholesterol metabolic process
Biological Processtriglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hormone-sensitive lipase
  • EC number
  • Alternative names
    • Monoacylglycerol lipase LIPE
    • Retinyl ester hydrolase

Gene names

    • Name
      lipeb

Organism names

  • Taxonomic identifier
  • Strain
    • Hd-rR
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A3B3HXB4

Proteomes

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Lipid droplet
Membrane, caveola

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-317Hormone-sensitive lipase N-terminal
Domain350-497Alpha/beta hydrolase fold-3
Domain578-654Alpha/beta hydrolase fold-3

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    695
  • Mass (Da)
    76,627
  • Last updated
    2018-12-05 v1
  • Checksum
    BC4D68FEBBD717C7
MDTKAVFAALYSVCEENATFFSAGGKVSQADSAKRLVESMKLIQEHARSLEPVISGFAAIYHHFDFDPLIPANGYRSLVKVVRCCLLHIIHKGRYIAANRRSIFFRAAHNAGEMEAYCSALCQLRALLYLAQRMLHDNSHGNLFFQDESGLSESFIREYASMHKGCFYGRCLGFQFTPAIRPCLQTIAIGLVAFGENYKRHQSGIGVAASSFFTSGKYAIDPELRGTEFERITQNLDVHFWKTFWNITETEVLSSLASMTSTQVKVNRALSVPPVAFDLPLAANHRASATIAPPSAHIGIAPIQMRLISYDLREGQDSETLLSMSRSEGGAISLSLGLKTKRLPSSPFLLIHFHGGGFVAQTSKSHEPYLKSWSQDLGVPILSVDYSLAPEAPFPRALEECFYAYCWALRNHHLLGWTGEKVCLAGDSAGGNLCVTTCMRAAAFGVRMPDGVVAAYPATLLTAYASPSRLLTLMDPLLPLSVLSRCLSAYAGSEPQTEKQVERVSTLSLVKRDTALFLRDFRQGASNWIHSLLDSNRETDPNISRDLSSVAIPPPAAEEGIELQHPREFPLGFEPLRSDQFAEMKLQSSPVFKDPFCSPLLAPDSMLKGLPPIHIVACALDPMLDDSVMFAKRLRSVDQPVTLCVVDDLPHGFLSLSQLSKETKEAANVCVERIRAVFLQDTPPEPRKKKALVHI

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H2MEH2H2MEH2_ORYLAlipeb862
A0A3B3HKY3A0A3B3HKY3_ORYLAlipeb691
A0A3B3IK45A0A3B3IK45_ORYLAlipeb743
A0A3B3II60A0A3B3II60_ORYLAlipeb694
A0A3B3IES8A0A3B3IES8_ORYLAlipeb753
A0A3B3IEF2A0A3B3IEF2_ORYLAlipeb855
A0A3B3I9S6A0A3B3I9S6_ORYLAlipeb807
A0A3B3H8M8A0A3B3H8M8_ORYLAlipeb825
A0A3B3I604A0A3B3I604_ORYLAlipeb741

Keywords

Genome annotation databases

Similar Proteins

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