A0A3B3HX68 · A0A3B3HX68_ORYLA

Function

function

Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.

Catalytic activity

Cofactor

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site57-60substrate
Binding site110substrate
Binding site115substrate
Active site222Tele-hemiaminal-histidine intermediate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionFAD-AMP lyase (cyclizing) activity
Molecular Functionglycerone kinase activity
Biological Processglycerol catabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Triokinase/FMN cyclase
  • EC number
  • Alternative names
    • Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

Gene names

    • Name
      tkfc

Organism names

  • Taxonomic identifier
  • Strain
    • Hd-rR
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A3B3HX68

Proteomes

Subcellular Location

Expression

Gene expression databases

Interaction

Subunit

Homodimer. Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-337DhaK
Domain373-574DhaL

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    580
  • Mass (Da)
    59,928
  • Last updated
    2018-12-05 v1
  • MD5 Checksum
    AB26B9858395510163A0BDB70AADB388
MEPQKKLINSVESCVDEALCGLVRASGGQSLLKGHRVVVRSDLQSLRGKVALVSGGGSGHEPAHGGYIGAGMLSAAVAGAVFASPPPASILAAILCMHNAGASGVLLVVKNYTGDRLNFGLAAEQARNQGVAVDMVIVADDCAFDLPSKAGRRGLCGTVFIHKLAGALAEEGCSLEHIVSRVREALKGIGTLGVSLSPCSVPGCLPSFQLPPGDMELGLGIHGEPGIKRSKVASADQVVETMLDHMTNPNSQSHLPLKAGDSVVLCVNNLGALSCLEMAVVTRAAIGCLESRGVLVARAMSGSFMTSLEMAGVSLSLMRADGELLRLFDADTSAPAWPNLSSACVSGRGYITEPPVMQTRPQDDTQVEGPLSPLMRRALEKVCSALLEKQEELNSLDRASGDGDCGTTHAQAARAAQEWLQGHVVPGCPGRLLSVLSGLVEEKMGGSSGALYSLFLTAAAGHVTQGQSDAAAWARAVHAGTQAMRRYGGADPGDRTMLDALCPVAEELMKLTTASPGGQKAVLRSAVQKASLGAEATRHMTARAGRASYIAADRVTLPDPGAVAVTAILRAVLETLEEEK

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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