Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoryFunctionSourceMGI: 1858896PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.Ho K.H., Candat A., Scarpetta V., Faucourt M., Weill S., Salio C., D'Este E., Meschkat M., Wurm C.A.[...], Patrizi A.View abstractCategoryFunctionSourceMGI: 1858896PubMedEurope PMCDev Cell 58:2641-2651.e6 (2023)Mapped to99+
Spastin is an essential regulator of male meiosis, acrosome formation, manchette structure and nuclear integrity.Cheers S.R., O'Connor A.E., Johnson T.K., Merriner D.J., O'Bryan M.K., Dunleavy J.E.M.View abstractCategoriesFunction, Subcellular LocationSourceMGI: 1858896PubMedEurope PMCDevelopment 150:dev201183-dev201183 (2023)Mapped to5
Modeling gain-of-function and loss-of-function components of SPAST-based hereditary spastic paraplegia using transgenic mice.Piermarini E., Akarsu S., Connors T., Kneussel M., Lane M.A., Morfini G., Karabay A., Baas P.W., Qiang L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1858896PubMedEurope PMCHum Mol Genet 31:1844-1859 (2022)Mapped to9
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.Bedogni F., Hevner R.F.View abstractCategoryFunctionSourceMGI: 1858896PubMedEurope PMCFront Mol Neurosci 14:686034-686034 (2021)Mapped to99+
Spastin depletion increases tubulin polyglutamylation and impairs kinesin- mediated neuronal transport, leading to working and associative memory deficits.Lopes A.T., Hausrat T.J., Heisler F.F., Gromova K.V., Lombino F.L., Fischer T., Ruschkies L., Breiden P., Thies E.[...], Kneussel M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1858896PubMedEurope PMCPLoS Biol 18:e3000820-e3000820 (2020)Mapped to5
Spastin Contributes to Neural Development through the Regulation of Microtubule Dynamics in the Primary Cilia of Neural Stem Cells.Jeong B., Kim T.H., Kim D.S., Shin W.H., Lee J.R., Kim N.S., Lee D.Y.View abstractCategoriesFunction, ExpressionSourceMGI: 1858896PubMedEurope PMCNeuroscience 411:76-85 (2019)Mapped to27
Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport.Magiera M.M., Bodakuntla S., Ziak J., Lacomme S., Marques Sousa P., Leboucher S., Hausrat T.J., Bosc C., Andrieux A.[...], Janke C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1858896PubMedEurope PMCEMBO J 37:e100440-e100440 (2018)Mapped to29
Spastin regulates VAMP7-containing vesicles trafficking in cortical neurons.Plaud C., Joshi V., Marinello M., Pastre D., Galli T., Curmi P.A., Burgo A.View abstractCategoriesFunction, Subcellular LocationSourceMGI: 1858896PubMedEurope PMCBiochim Biophys Acta Mol Basis Dis 1863:1666-1677 (2017)Mapped to7
Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia.Allison R., Edgar J.R., Pearson G., Rizo T., Newton T., Gunther S., Berner F., Hague J., Connell J.W.[...], Reid E.View abstractCategoriesFunction, Subcellular LocationSourceMGI: 1858896PubMedEurope PMCJ Cell Biol 216:1337-1355 (2017)Mapped to5
Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.Brill M.S., Kleele T., Ruschkies L., Wang M., Marahori N.A., Reuter M.S., Hausrat T.J., Weigand E., Fisher M.[...], Misgeld T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1858896PubMedEurope PMCNeuron 92:845-856 (2016)Mapped to10
Quantitative Gait Analysis Using a Motorized Treadmill System Sensitively Detects Motor Abnormalities in Mice Expressing ATPase Defective Spastin.Connell J.W., Allison R., Reid E.View abstractCategoryPhenotypes & VariantsSourceMGI: 1858896PubMedEurope PMCPLoS One 11:e0152413-e0152413 (2016)Mapped to5
Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.Eom T.Y., Stanco A., Guo J., Wilkins G., Deslauriers D., Yan J., Monckton C., Blair J., Oon E.[...], Anton E.S.View abstractCategoryFunctionSourceMGI: 1858896PubMedEurope PMCDev Cell 31:677-689 (2014)Mapped to99+
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.Koscielny G., Yaikhom G., Iyer V., Meehan T.F., Morgan H., Atienza-Herrero J., Blake A., Chen C.K., Easty R.[...], Parkinson H.View abstractCategoryFunctionSourceMGI: 1858896PubMedEurope PMCNucleic Acids Res 42:D802-9 (2014)Mapped to99+
Amyloid-beta oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin.Zempel H., Luedtke J., Kumar Y., Biernat J., Dawson H., Mandelkow E., Mandelkow E.M.View abstractCategoriesFunction, InteractionSourceMGI: 1858896PubMedEurope PMCEMBO J 32:2920-2937 (2013)Mapped to20
Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.Fassier C., Tarrade A., Peris L., Courageot S., Mailly P., Dalard C., Delga S., Roblot N., Lefevre J.[...], Melki J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1858896PubMedEurope PMCDis. Model. Mech. 6:72-83 (2013)Cited in1Mapped to4
A conditional knockout resource for the genome-wide study of mouse gene function.Skarnes W.C., Rosen B., West A.P., Koutsourakis M., Bushell W., Iyer V., Mujica A.O., Thomas M., Harrow J.[...], Bradley A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1858896PubMedEurope PMCNature 474:337-342 (2011)Mapped to99+
Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia.Murmu R.P., Martin E., Rastetter A., Esteves T., Muriel M.P., El Hachimi K.H., Denora P.S., Dauphin A., Fernandez J.C.[...], Stevanin G.View abstractCategorySubcellular LocationSourceMGI: 1858896PubMedEurope PMCMol Cell Neurosci 47:191-202 (2011)Mapped to17
Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.Lacroix B., van Dijk J., Gold N.D., Guizetti J., Aldrian-Herrada G., Rogowski K., Gerlich D.W., Janke C.View abstractCategoryFunctionSourceMGI: 1858896PubMedEurope PMCJ. Cell Biol. 189:945-954 (2010)Cited in5Mapped to49
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.Kasher P.R., De Vos K.J., Wharton S.B., Manser C., Bennett E.J., Bingley M., Wood J.D., Milner R., McDermott C.J.[...], Grierson A.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1858896PubMedEurope PMCJ. Neurochem. 110:34-44 (2009)Cited in1Mapped to4
Pleiotropic effects of spastin on neurite growth depending on expression levels.Riano E., Martignoni M., Mancuso G., Cartelli D., Crippa F., Toldo I., Siciliano G., Di Bella D., Taroni F.[...], Rugarli E.I.View abstractCategoryFunctionSourceMGI: 1858896PubMedEurope PMCJ. Neurochem. 108:1277-1288 (2009)Cited in1Mapped to8
A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition.Tarrade A., Fassier C., Courageot S., Charvin D., Vitte J., Peris L., Thorel A., Mouisel E., Fonknechten N.[...], Melki J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1858896PubMedEurope PMCHum. Mol. Genet. 15:3544-3558 (2006)Cited in1Mapped to4
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.Magdaleno S., Jensen P., Brumwell C.L., Seal A., Lehman K., Asbury A., Cheung T., Cornelius T., Batten D.M.[...], Curran T.CategoriesFunction, ExpressionSourceMGI: 1858896PubMedEurope PMCPLoS Biol 4:e86-e86 (2006)Mapped to99+
Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus.Claudiani P., Riano E., Errico A., Andolfi G., Rugarli E.I.View abstractCategorySubcellular LocationSourceMGI: 1858896PubMedEurope PMCExp. Cell Res. 309:358-369 (2005)Cited in2Mapped to4
A gene-driven ENU-based approach to generating an allelic series in any gene.Quwailid M.M., Hugill A., Dear N., Vizor L., Wells S., Horner E., Fuller S., Weedon J., McMath H.[...], Cox R.D.View abstractCategoryPhenotypes & VariantsSourceMGI: 1858896PubMedEurope PMCMamm Genome 15:585-591 (2004)Mapped to64