A0A3A8PDW9 · A0A3A8PDW9_9BACT

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site166-168NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • ORF names
      D7W81_38215

Organism names

  • Taxonomic identifier
  • Strain
    • AB050A
  • Taxonomic lineage
    Bacteria > Myxococcota > Myxococcia > Myxococcales > Cystobacterineae > Myxococcaceae > Corallococcus

Accessions

  • Primary accession
    A0A3A8PDW9

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-121Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain124-280Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    283
  • Mass (Da)
    29,914
  • Last updated
    2018-12-05 v1
  • Checksum
    7FCB261CE307F62D
MTAQLIDGKAVAARVRAEIKEEVARLKAERGITPGLAVVRVGEDPASKIYVTGKKKAAEEVGFNSWEHHPDETITQAELLALVHRLNEDPAVHGILVQLPLPKHLDADAIISAVKPEKDADGFHPMNAGNLLLGRPATRACTPYGVMRLLEEVGCNPAGKRAVVVGRSNIVGKPQALMLLQKDATVTVCHRKSDLPAEVAQADILVVAVGVPELVKGAWIKPGAVVIDVGMNRKADGKLVGDVEFAAAAERASFITPVPGGVGPMTIAMLMKNTLEAAQRAGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RAWK01000382
EMBL· GenBank· DDBJ
RKH54543.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp