A0A3A6VPK7 · A0A3A6VPK7_LEGPN
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids197 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 46 | substrate | |||
Binding site | 46-47 | ATP (UniProtKB | ChEBI) | |||
Binding site | 54 | ATP (UniProtKB | ChEBI) | |||
Site | 54 | Transition state stabilizer | |||
Binding site | 78 | substrate | |||
Binding site | 110 | substrate | |||
Binding site | 124 | substrate | |||
Binding site | 125-127 | ATP (UniProtKB | ChEBI) | |||
Binding site | 135 | ATP (UniProtKB | ChEBI) | |||
Binding site | 160-166 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Legionellales > Legionellaceae > Legionella
Accessions
- Primary accessionA0A3A6VPK7
Proteomes
Subcellular Location
Interaction
Subunit
Homohexamer.
Structure
Sequence
- Sequence statusComplete
- Length197
- Mass (Da)22,368
- Last updated2018-12-05 v1
- MD5 Checksum1CA5205A65DBB39A6CFABFF0AC06C4DF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QWDR01000001 EMBL· GenBank· DDBJ | RJY33486.1 EMBL· GenBank· DDBJ | Genomic DNA |