A0A3A6NDJ4 · A0A3A6NDJ4_9BACT

  • Protein
    Glyceraldehyde-3-phosphate dehydrogenase
  • Gene
    gap
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site12-13NAD+ (UniProtKB | ChEBI)
Binding site38NAD+ (UniProtKB | ChEBI)
Binding site92NAD+ (UniProtKB | ChEBI)
Binding site134NAD+ (UniProtKB | ChEBI)
Binding site165-167D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Active site166Nucleophile
Site194Activates thiol group during catalysis
Binding site197D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site226-227D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site249D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site335NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Biological Processglucose metabolic process
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glyceraldehyde-3-phosphate dehydrogenase
  • EC number

Gene names

    • Name
      gap
    • ORF names
      C4531_17065

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SURF_16
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfobulbia > Desulfobulbales > Desulfobulbaceae > Desulfurivibrio

Accessions

  • Primary accession
    A0A3A6NDJ4

Proteomes

Subcellular Location

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-166Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    355
  • Mass (Da)
    38,757
  • Last updated
    2018-12-05 v1
  • Checksum
    3C931098FBE3A66B
MATKVAINGFGRIGRLVLQAMMEKGVAGKDFEVVAVVDVSTDARHFAYQLKYDTVHGRFKGTLATKKSNPSLAEDDVIVVNGQEILCVASARTPDLLPWKSLGVEYVVESTGLFTDYEKAKLHLQAGAKKVLITAPAKGGVKTFVMGVNEGEYDPKTHHIVSNASCTTNGLAPLVHVMLKEGIGIDKGAMTTIHSYTATQKIVDGPSRKTWREGRAAAMNIIPSSTGAAKALHEVIPSMKGKLIGMAFRVPTPDVSVIDFTFRTIRESSIEEIDAAMKKASESYLQGILEYTDEEVVSTDFIHSSSSSIYDSLTTRRNNFKDETNAFKVIAWYDNEWGYSNRVVDLLSHMLSVTA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QZKJ01000112
EMBL· GenBank· DDBJ
RJX25537.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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