A0A3A6NDI2 · A0A3A6NDI2_9BACT

  • Protein
    Succinate--CoA ligase [ADP-forming] subunit alpha
  • Gene
    sucD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site17-20CoA (UniProtKB | ChEBI)
Binding site43CoA (UniProtKB | ChEBI)
Binding site96-98CoA (UniProtKB | ChEBI)
Binding site160substrate; ligand shared with subunit beta
Active site248Tele-phosphohistidine intermediate

GO annotations

AspectTerm
Cellular Componentsuccinate-CoA ligase complex (ADP-forming)
Molecular Functionnucleotide binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit alpha
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit alpha
      (SCS-alpha
      )

Gene names

    • Name
      sucD
    • ORF names
      C4531_18300

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SURF_16
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfobulbia > Desulfobulbales > Desulfobulbaceae > Desulfurivibrio

Accessions

  • Primary accession
    A0A3A6NDI2

Proteomes

Subcellular Location

Interaction

Subunit

Heterotetramer of two alpha and two beta subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-100CoA-binding

Sequence similarities

Belongs to the succinate/malate CoA ligase alpha subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    294
  • Mass (Da)
    30,450
  • Last updated
    2018-12-05 v1
  • Checksum
    78A3B8E700F36CB2
MSIFVDHSTRLVVQGITGREGRFHNRQCRDYGTRIVAGVTPGKGGSEVDGIPVFNTVRSALARTEANTSLIFVPPAFAADAICEAADAGVPLIICITEGIPVHDMLRVKQYLRLTGARLIGPNSPGIISPGLCKAGIMPAAIHLAGGPIGVVSRSGTLTYEVVHQLTRQGIGQTTCIGIGGDPVTGTSFIDCLAAFAQDPATRGMVMVGEIGGKAEEEAALYVRQHVTKPVAGFIAGLTAPPGRRMGHAGAIVSGGSGTALGKIAAMREGGIQVCEDLGRLGEFCREIFSHVLA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QZKJ01000118
EMBL· GenBank· DDBJ
RJX24888.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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