A0A3A5LQN3 · A0A3A5LQN3_STAAU
- Protein3-dehydroquinate synthase
- GenearoB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids354 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Catalytic activity
- 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
Cofactor
Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )
Note: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 100-104 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 124-125 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 136 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 145 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 163-166 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 178 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 242 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 256 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-dehydroquinate synthase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-dehydroquinate synthase
- EC number
- Short namesDHQS
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionA0A3A5LQN3
- Secondary accessions
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 62-316 | 3-dehydroquinate synthase | |||
Sequence similarities
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length354
- Mass (Da)40,237
- Last updated2018-12-05 v1
- Checksum59AB2D0C089B872D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAIIGN010000001 EMBL· GenBank· DDBJ | CAC8215039.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BDVT01000001 EMBL· GenBank· DDBJ | GBV19341.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAALTR010000315 EMBL· GenBank· DDBJ | NGW68405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QNXH01000001 EMBL· GenBank· DDBJ | TXL38908.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QNXF01000002 EMBL· GenBank· DDBJ | TXL46896.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP152420 EMBL· GenBank· DDBJ | XAJ30604.1 EMBL· GenBank· DDBJ | Genomic DNA |