A0A3A5L174 · A0A3A5L174_9GAMM

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      D6J04_13200
      , DIZ67_13495

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • WH04
    • 4570-18-6
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Legionellales > Legionellaceae > Legionella

Accessions

  • Primary accession
    A0A3A5L174

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane17-35Helical
Transmembrane58-80Helical
Transmembrane87-104Helical
Transmembrane110-131Helical
Transmembrane143-165Helical
Transmembrane177-197Helical
Transmembrane228-252Helical
Transmembrane264-284Helical
Transmembrane296-315Helical
Transmembrane321-339Helical
Transmembrane346-366Helical
Transmembrane394-415Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-416Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    425
  • Mass (Da)
    47,065
  • Last updated
    2019-04-10 v1
  • Checksum
    A8C995B0101F01E0
MQMVGEYREETKASLRILPWVVCFSASLFFFYEFIQGNMFASIADNIMHDFQIQADKMAYLSSIYYLSNVLFLFVAGMVLDKYSNKKTILFAMFLCVVSTFILAHAQSFYLALLCRFITGIGSAFCFLGPIRIASRWFPPRRMAMITGAVVTMAMTGGMLSQYPLTKLVAQVGWRDALIQVGWLGTAMLIFMCFGIVEKKQTVTGDSKKIDVKTIIRKAYLNSQNLRAALYTSLMNMAIAVFGAMMGSLYLMQRLDISKEEASLVNTMLFLGAIFGGPVIGWISDKLALRIMPMKIGVLASLATVLVILFVPVSLPVMKVLFFLLGFFTAAQVISYALVAESSSPLMTATAVSVISILTQGGYIVYQNVFSQLLMHHGEMRMVQGVPVYSLGDYQYAALMLPVGLIIALLALTGLRETHGRHIEG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QZWB01000018
EMBL· GenBank· DDBJ
RJT43956.1
EMBL· GenBank· DDBJ
Genomic DNA
QFGE01000016
EMBL· GenBank· DDBJ
TID32497.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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