A0A3A5HLC8 · A0A3A5HLC8_9EURY
- ProteinCatalase-peroxidase
- GenekatG
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids724 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
Catalytic activity
- 2 H2O2 = 2 H2O + O2
Cofactor
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
Features
Showing features for site, active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | catalase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | hydrogen peroxide catabolic process | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCatalase-peroxidase
- EC number
- Short namesCP
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobacterium
Accessions
- Primary accessionA0A3A5HLC8
Proteomes
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Cross-link | 210↔236 | Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-87) | ||||
Sequence: YVNPEGPDGKPDPVAAARDIRESFARM |
Post-translational modification
Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
Interaction
Subunit
Homodimer or homotetramer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 121-418 | Plant heme peroxidase family profile | ||||
Sequence: LDKARRLLWPIKQKYGRKISWADLMILVGNVALESMGFKTFGFGGGREDIWEPEKDIYWGSESEWLEDERYTGDRELENPLAAVQMGLIYVNPEGPDGKPDPVAAARDIRESFARMAMNDEETVALIAGGHAFGKTHGAGDPSLVGPEPEAAPIQEQGLGWKSKFGTGKGNDTITGGPEVIWTNTPIKWDNNFFRILFEFEWELTKSPAGAYQWKPKGDAGDGTVPDPHDSSKRRTPGMLTTDLSLRLDPDYEKISRRFYENPDQFADAFARAWFKLTHRDMGPLSRYLGPEVPEEEL | ||||||
Region | 331-358 | Disordered | ||||
Sequence: AYQWKPKGDAGDGTVPDPHDSSKRRTPG | ||||||
Compositional bias | 342-356 | Basic and acidic residues | ||||
Sequence: DGTVPDPHDSSKRRT |
Sequence similarities
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length724
- Mass (Da)81,421
- Last updated2018-12-05 v1
- Checksum79185C3441C304F9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 342-356 | Basic and acidic residues | ||||
Sequence: DGTVPDPHDSSKRRT |