A0A3A2IV93 · A0A3A2IV93_STAAU

  • Protein
    L-threonine dehydratase catabolic TdcB
  • Gene
    tdcB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4.

GO annotations

AspectTerm
Molecular FunctionL-serine ammonia-lyase activity
Molecular Functionnucleotide binding
Molecular Functionpyridoxal phosphate binding
Molecular Functionthreonine deaminase activity
Biological Processisoleucine biosynthetic process
Biological ProcessL-serine catabolic process
Biological ProcessL-threonine catabolic process to propionate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-threonine dehydratase catabolic TdcB
  • EC number
  • Alternative names
    • Threonine deaminase

Gene names

    • Name
      tdcB
    • Synonyms
      ilvA_1
    • ORF names
      DQU50_03355
      , DQU51_15610
      , G0Z31_08815
      , G6Y24_13290
      , GO793_13900
      , GO941_09835
      , GQX52_04905
      , GZ111_001045
      , M1K003_0280
      , SAMEA4552975_00461
      , SAMEA70153168_00426

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • M1K003
    • pt013
    • Pt013
    • Pt014
    • pt014
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A3A2IV93
  • Secondary accessions
    • A0A4P7P631

Proteomes

Interaction

Subunit

In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-319Tryptophan synthase beta chain-like PALP

Sequence similarities

Belongs to the serine/threonine dehydratase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    346
  • Mass (Da)
    37,147
  • Last updated
    2018-12-05 v1
  • Checksum
    4435206B7E89CC10
MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQNITKGNVYLKLENMQFTGSFKFRGASNKINHLSDEQKAKGIIGASAGNHAQGVALTAKLLGIDATIVMPETAPIAKQNATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYDDKFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQAENVHGMAESFYKRALTEHREDSTIADGCDVKVPGEKTYEVVKHLVDEFILVSEEEIEHAMQDLMQRAKIITEGAGALPTAAILSGKIDKKWLEGKNVVALVSGGNVDLTRVSGVIEHGLNIADTSKGVVG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAIHOM010000001
EMBL· GenBank· DDBJ
CAC6984673.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIIGN010000001
EMBL· GenBank· DDBJ
CAC8215438.1
EMBL· GenBank· DDBJ
Genomic DNA
BDVT01000001
EMBL· GenBank· DDBJ
GBV19314.1
EMBL· GenBank· DDBJ
Genomic DNA
WPRH01000733
EMBL· GenBank· DDBJ
MVI56942.1
EMBL· GenBank· DDBJ
Genomic DNA
WPVZ01000535
EMBL· GenBank· DDBJ
MVL45785.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAJIY010000025
EMBL· GenBank· DDBJ
NGK21606.1
EMBL· GenBank· DDBJ
Genomic DNA
JAALTR010000315
EMBL· GenBank· DDBJ
NGW68432.1
EMBL· GenBank· DDBJ
Genomic DNA
JAANDN010000049
EMBL· GenBank· DDBJ
NUY67989.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXH01000001
EMBL· GenBank· DDBJ
TXL38881.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXF01000002
EMBL· GenBank· DDBJ
TXL46869.1
EMBL· GenBank· DDBJ
Genomic DNA
CP152420
EMBL· GenBank· DDBJ
XAJ30630.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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