A0A3A1XS24 · A0A3A1XS24_9BIFI

Function

function

Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site16-21ATP (UniProtKB | ChEBI)
Binding site20Mg2+ (UniProtKB | ChEBI)
Binding site38substrate
Binding site62substrate
Binding site91substrate
Binding site133ATP (UniProtKB | ChEBI)
Binding site152substrate
Binding site253-258NAD+ (UniProtKB | ChEBI)
Binding site287-291NAD+ (UniProtKB | ChEBI)
Binding site311-312NAD+ (UniProtKB | ChEBI)
Binding site324NAD+ (UniProtKB | ChEBI)
Binding site333NAD+ (UniProtKB | ChEBI)
Binding site351-354NAD+ (UniProtKB | ChEBI)
Binding site366Zn2+ (UniProtKB | ChEBI)
Binding site441Zn2+ (UniProtKB | ChEBI)
Binding site457Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-dehydroquinate synthase activity
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionshikimate kinase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Shikimate kinase
  • EC number
  • Short names
    SK
  • Recommended name
    3-dehydroquinate synthase
  • EC number
  • Short names
    DHQS

Gene names

    • Name
      aroB
    • Synonyms
      aroK
    • ORF names
      CJI49_04285

Organism names

Accessions

  • Primary accession
    A0A3A1XS24

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain249-5223-dehydroquinate synthase

Sequence similarities

Belongs to the shikimate kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    560
  • Mass (Da)
    61,910
  • Last updated
    2018-12-05 v1
  • Checksum
    7A5563D189D09AA6
MSNTKLPLAVIIGMPAAGKTRVGREVAHLMNLPFYDTDDMIECDIDMSIPQYFEEYGQDAFRKIEARIVREAILGDTPTEDSTKGIVSLGGGAPMREETQKVLREYMRCGGRVVYLQANAKEAIERASWNNNRPMFSGEDAQKRWMELFEQRDPVFRAVSNIHMQTKGSTPYMAAEKLRSMIMQRIVHVTGEGIEPYDVRIGDGAMQLLPQMLGTKPVKVALVHTQPVQRHSDKARTILRQSGYEVFDMLIPDAEAGKTIKVASGLWANLAEAGFTRSDAIVGLGGGAATDVAGFVAATWMRGIRYVNCPTSLLAMVDASTGGKTGINTDAGKNLVGSFYTPAGVLADTSTLATLPNDILIEGLGEVAKSGFIRDGEILKILSDANNARLLREFNGDDLENNNELHELLVELIERTVKVKAYHVSSDLKEQGLREFLNYGHTLGHAIEQIEHFRWRHGNAVAVGMVFAAELAQILGYLDARDVAYHRSLLDSLGLPTSWQCAKDADAAFECVLNLMHRDKKARGNMLRFVILDGISNPMHLDNPPIEAVREAFERVYKQK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NQOQ01000002
EMBL· GenBank· DDBJ
RIY28783.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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