A0A398AAH5 · A0A398AAH5_BRACM

Function

function

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Catalytic activity

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentMCM complex
Cellular ComponentTHO complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular FunctionDNA helicase activity
Biological ProcessDNA replication initiation
Biological ProcessDNA unwinding involved in DNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication licensing factor MCM4
  • EC number

Gene names

    • ORF names
      BRARA_C04147

Organism names

  • Taxonomic identifier
  • Strain
    • cv. B-3
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Brassiceae > Brassica

Accessions

  • Primary accession
    A0A398AAH5

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Component of the MCM2-7 complex.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-47Polar residues
Region1-106Disordered
Compositional bias62-81Polar residues
Domain419-625MCM

Sequence similarities

Belongs to the MCM family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    831
  • Mass (Da)
    92,107
  • Last updated
    2018-12-05 v1
  • Checksum
    F85E9CED51E08CE2
MASDSPPANTNDGPSSPGENASSPIGNTYSSPSSLRSRRRARSSTPSQFATPPPPSRLGVPNSTPPTSRPSAARSNRPATPSHTDEPPPSSDDGGEDGADDATPTFVWGTNISVQDVKSAIEMFVKHFREAKESSDDLFREGKYMASIRKVIEIEGEWIDVDAYDVFDYDPDLYNKMVRYPLEVLAIFDIVLMDIVSSIDRLFEKHVQVRIFNLRSSTSMRNLNPSDIEKMISLKGMIIRSSSIIPEIREAVFRCLVCGYFSDPIIVDRGKISEPPTCLKQECLAKNSMTLVHNRCRFADKQIVRLQETPDEIPEGGTPHTVSLLLHDKLVDNGKPGDRIEVTGIYRAMTVRVGPAHRTVKSVFKTYIDCLHIKKASKTRMAAEDPMDVDNSLRRVDEDVELDEEKLKKFEELSKQPDIYEKLARSLAPNIWELDDVKKGLLCQLFGGNALNLASGANFRGDINILLVGDPGTSKSQLLQYIHKLSPRGIYTSGRGSSAVGLTAYVAKDPETGETVLESGALVLSDRGICCIDEFDKMSDSARSMLHEVMEQQTVSIAKAGIIASLNARTSVLACANPSGSRYNPRLSVIENIHLPPTLLSRFDLIYLILDKPDEQTDRRLAKHIVALHFENAESAQEEALDITTLTSYVSYARKNIHPKLSDEAAEELTRGYVELRKAGKFAGSSKKVITATPRQIESLIRLSEALARMRFSEWVEKHDVEEAFRLLRVAMQQSATDHATGTIDMDLINTGVSASERMRRDILVSSIRDITLEKMQIGGSAMRLSELLEELKKHGGNINTEIHLHDVRKAVGTLASEGFLVTEGDRIKRI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-47Polar residues
Compositional bias62-81Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM010630
EMBL· GenBank· DDBJ
RID72246.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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