A0A397ZWT5 · A0A397ZWT5_BRACM

Function

function

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site22ATP (UniProtKB | ChEBI)
Binding site24ATP (UniProtKB | ChEBI)
Binding site25ATP (UniProtKB | ChEBI)
Binding site26ATP (UniProtKB | ChEBI)
Binding site27ATP (UniProtKB | ChEBI)
Binding site118ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processphosphorylation
Biological Processribosomal small subunit biogenesis
Biological ProcessrRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase isoenzyme 6 homolog
  • EC number
  • Short names
    AK6
  • Alternative names
    • Dual activity adenylate kinase/ATPase
      (AK/ATPase
      )

Gene names

    • ORF names
      BRAA03T10433Z
      , BRARA_C01043

Organism names

  • Taxonomic identifier
  • Strain
    • cv. B-3
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Brassiceae > Brassica

Accessions

  • Primary accession
    A0A397ZWT5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-25Disordered
Region42-65NMPbind
Region117-127LID

Sequence similarities

Belongs to the adenylate kinase family. AK6 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    177
  • Mass (Da)
    19,797
  • Last updated
    2018-12-05 v1
  • MD5 Checksum
    A75F3F3D2D1FC7F0B976690BB06B3055
MAGANSGTRRQKPNILITGTPGTGKSTTASALAEATSFKHICVGDLVKDKNLHDGWDDQFESHVINEDLVVDELEDVMEGGGNIVDYHGCDFFPERWFDLVVVLQTENSILYDRLTRRGYSGTKLSNNIECEIFQVMLEEASDSYEEEIVTAMQSDTIEDIDDNVASLTEWIQSWKP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM010630
EMBL· GenBank· DDBJ
RID68914.1
EMBL· GenBank· DDBJ
Genomic DNA
LR031572
EMBL· GenBank· DDBJ
VDC79215.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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