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A0A397SAS6 · A0A397SAS6_9GLOM

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      C1645_700467

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DAOM 227022
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Glomeromycotina > Glomeromycetes > Glomerales > Glomeraceae > Glomus

Accessions

  • Primary accession
    A0A397SAS6

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane101-124Helical
Transmembrane144-165Helical
Transmembrane172-190Helical
Transmembrane196-216Helical
Transmembrane228-255Helical
Transmembrane267-287Helical
Transmembrane324-345Helical
Transmembrane360-379Helical
Transmembrane411-433Helical
Transmembrane488-510Helical
Transmembrane576-599Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-45Disordered
Compositional bias25-45Polar residues
Region61-91Disordered
Compositional bias69-86Basic and acidic residues
Domain106-515Major facilitator superfamily (MFS) profile

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    613
  • Mass (Da)
    67,810
  • Last updated
    2018-12-05 v1
  • MD5 Checksum
    AB7E2B5374D15710AA2FE372776AF530
MEQINLTTISTKLSEEEDTDEESDSPSFTPTTLPTSFSTPTVSENSEILDDKEWLIKNKRISTGGSSRRSHHNGEHAGDHLRGQTSGSRRKSLKVDNADHIIKMCAMACACTFGVGSHFASHIIGPMKGILMEQLDLTNTQFSLLVASLTLCNTVIPIVSGLLVARFGTTRSSLVITTIILLGMIIFTAASWNGKVGLMIAGFIVFGMGLAPLTIVQETIIVQFFQGNGLGFALAVGLTLGRLASFVATVLAVPLSLMEPLTYRTPFIVATATCAVSWIMNIVYVYILKHADNRKNHNKEGVALHSVVEKKAVHWNAIFDLSDIFWWFLVVGILFGASMSPFLHLSSNIIKHRFDTTDMLAAWDSSVILLLPVILYPFLGLFLDKFGFRFISITYLLLLSPPNLIHPFPPIFLFAVAYAAVPLTMVTLIPLLTKNVSTGLGLLKSVDNIGATLSQTFAGILLDEHVRHKKYIIDDEGIEYGHEDDDLVALRMFAILSSFLFLVSLVFWWMDKTYKGGSLNAKYEGEYHNDNTNNYGQLRSSDDDDEVHSAGLMRMIVIEEEISFVRDESIKKRKRTIIYMGILGLMMIICWIVFGVVAFEKAGISASDEKVSE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias25-45Polar residues
Compositional bias69-86Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QKYT01000723
EMBL· GenBank· DDBJ
RIA81959.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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