A0A395NRF5 · A0A395NRF5_TRIAR
- ProteinAdenylate kinase isoenzyme 6 homolog
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1757 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
Catalytic activity
- AMP + ATP = 2 ADP
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 169-176 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1598 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1600 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1601 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1602 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1603 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1694 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | myosin complex | |
Cellular Component | nucleus | |
Cellular Component | vesicle | |
Molecular Function | actin filament binding | |
Molecular Function | adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | microfilament motor activity | |
Biological Process | actin filament organization | |
Biological Process | phosphorylation | |
Biological Process | ribosomal small subunit biogenesis | |
Biological Process | rRNA processing | |
Biological Process | vesicle transport along actin filament |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate kinase isoenzyme 6 homolog
- EC number
- Short namesAK6
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Hypocreaceae > Trichoderma
Accessions
- Primary accessionA0A395NRF5
Proteomes
Interaction
Subunit
Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 6-61 | Myosin N-terminal SH3-like | |||
Domain | 75-783 | Myosin motor | |||
Region | 658-680 | Actin-binding | |||
Coiled coil | 918-1081 | ||||
Region | 1110-1131 | Disordered | |||
Domain | 1230-1499 | Dilute | |||
Region | 1618-1641 | NMPbind | |||
Region | 1693-1703 | LID | |||
Sequence similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Belongs to the adenylate kinase family. AK6 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,757
- Mass (Da)199,899
- Last updated2018-12-05 v1
- MD5 Checksum25D04B8B57846499D9EB52811139F24D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
PXOA01000198 EMBL· GenBank· DDBJ | RFU78656.1 EMBL· GenBank· DDBJ | Genomic DNA |