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A0A395NRF5 · A0A395NRF5_TRIAR

  • Protein
    Adenylate kinase isoenzyme 6 homolog
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site169-176ATP (UniProtKB | ChEBI)
Binding site1598ATP (UniProtKB | ChEBI)
Binding site1600ATP (UniProtKB | ChEBI)
Binding site1601ATP (UniProtKB | ChEBI)
Binding site1602ATP (UniProtKB | ChEBI)
Binding site1603ATP (UniProtKB | ChEBI)
Binding site1694ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmyosin complex
Cellular Componentnucleus
Cellular Componentvesicle
Molecular Functionactin filament binding
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionmicrofilament motor activity
Biological Processactin filament organization
Biological Processphosphorylation
Biological Processribosomal small subunit biogenesis
Biological ProcessrRNA processing
Biological Processvesicle transport along actin filament

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase isoenzyme 6 homolog
  • EC number
  • Short names
    AK6
  • Alternative names
    • Dual activity adenylate kinase/ATPase
      (AK/ATPase
      )

Gene names

    • ORF names
      TARUN_3550

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IBT 40837
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Hypocreaceae > Trichoderma

Accessions

  • Primary accession
    A0A395NRF5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, coiled coil.

Type
IDPosition(s)Description
Domain6-61Myosin N-terminal SH3-like
Domain75-783Myosin motor
Region658-680Actin-binding
Coiled coil918-1081
Region1110-1131Disordered
Domain1230-1499Dilute
Region1618-1641NMPbind
Region1693-1703LID

Sequence similarities

Belongs to the adenylate kinase family. AK6 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,757
  • Mass (Da)
    199,899
  • Last updated
    2018-12-05 v1
  • MD5 Checksum
    25D04B8B57846499D9EB52811139F24D
MAATYDVGTRAWQPDAAEGWVASELISKTVEGNKTKLVFQLDNGETRTVDVSTEALQSGGSDPSLPPLMNPTILEASDDLTNLSHLNEPAVLQAIRLRYLQKEIYTYSGIVLIATNPFARVDSLYVPGMVQVYAGKQRATQAPHLFAIAEEAFMDMIRDGKNQTIVVSGESGAGKTVSAKYIMRYFATRESPDNPGARTKRGAEQMSETEEQILATNPIMEAFGNAKTTRNDNSSRFGKYIEIMFDDKTNIIGAKIRTYLLERSRLVFQPLKERNYHIFYQLVAGASDEEREALHILPIEQFEYLNQGDCPTIDGVDDKAEFDATKKSLHTIGVSETQQADIFKLLAGLLHLGNVKITASRNDSVLAPNEPSLELACGILGVDATEFAKWIVKKQLVTRGEKISSNLSQAQAIVVRDSVAKFIYSSLFDWLVEIINLSLATEEVLSRVTSFIGVLDIYGFEHFAKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYLREQIDWTFIDFSDNQPCIDLIEGKMGILSLLDEESRLPMGSDDQFVTKLHHNFATEKKQPFFKKPRFGKSAFTVCHYAVDVTYESEGFIEKNRDTVPDEHMAVLRATSNSFLKQVLDAASAVREKDVASASSNAVKPAAGRKIGVAVNRKPTLGGIFRSSLIELMNTINNTDVHYIRCIKPNEAKEAWQFEGPMVLSQLRACGVLETVRISCAGYPTRWTYEEFALRYYMLVHSSQLTSEIRQMADAILTKALGTSTGKGLDKYQLGLTKIFFRAGMLAFLENLRTSRLNECAILIQKNLRAKFYRRRYLEARESIVQTQSAIRAYLARKQALELRTIRAATTIQRVWRGYKQRKEFLRIRKNLVLFESVAKGYLRRKNIMETRVGNAALVIQRVWRQRTQLRTWRLYRKKVILIQSLWRGRSARQEYKKMREEARDLKQISYKLENKVVELTQNLGSMKEKNKNLVSQVESYEGQLKSWKNRHNALEARTKELQTEANQAGIAVARLQAMEDEMKKLQQAFDESTMNIKRMQEEERELRESLRLTSSELETTKETNLERERDNMSLRQELEALRDALELAKRNGSLNGEITNGVSSAPAVASGLINLVSSKKPKRRSAGAEPRELDRLSGTYNPRPVSMAVTSSLHRQNLSGATFIPGVDNIEMELESLLADEDGLNEEVTMGLIRNLKIPSPNTNPPPSDKEVLFPSYLINLVTSEMWNNGFVKESERFLANVMQSIQQEVMQHDGDEAVNPGAFWLSNVHEMLSFVFLAEDWYQTQKTDNYEYDRLLEIVKHDLESLEFNIYHTWMKVLKKKLQKMIIPAIIESQSLPGFITNESNRFLGKLLQSNSAPAYSMDNLLSLLNSVFRAMKAYYLEDSIITQTITELLHLVGVTAFNDLLMRRNFLSWKRGLQINYNITRIEEWCKSHDMPEGTLQLEHLMQATKLLQLKKATLNDIEIIQDICWMLSPNQIQKLLNQYLVADYEQPINGEIMKAVASRVTEKSDVLLLQAVDMEDSGPYEIAEPRVITALETYTPSWLQTPRLKRLAEIVSAQAIAQQEKLEAGDVDGFDGHQQLAEVEESETEQTMRSAPNIIITGTPGVGKTTHSEILAERTGLRHFSVNQVVKDKECHEGWSDEYQSWIVDEDKLLDVIEDDVKAGGCIIDWHACDLFPRSWIDLVVVLRVDSATLYDRLQARNYAEAKLQENIDSEIMEVLLQEAREAFDEEIVVELTSNSSTEMESNMDRIEAWIKQWKTDHAD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PXOA01000198
EMBL· GenBank· DDBJ
RFU78656.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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