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A0A395M5Q3 · A0A395M5Q3_9HYPO

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      FIE12Z_12587

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NRRL 13405
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium incarnatum-equiseti species complex

Accessions

  • Primary accession
    A0A395M5Q3

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane35-58Helical
Transmembrane105-124Helical
Transmembrane196-218Helical
Transmembrane253-275Helical
Transmembrane295-315Helical
Transmembrane322-342Helical
Transmembrane348-367Helical
Transmembrane388-406Helical
Transmembrane418-440Helical
Transmembrane483-504Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-29Disordered
Domain37-442Major facilitator superfamily (MFS) profile

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    510
  • Mass (Da)
    55,482
  • Last updated
    2018-12-05 v1
  • MD5 Checksum
    D08899E6AFAC6961B42C1D2B38EDFDC9
MDSSKEARDVTNVAASDQSDNEDHGKKPVPTSMKILSVVIVSMIGFGGHWSSGVTGALKSTLKKELHISNTQYAVLDTSENFIKTALILVSGVLTDRYGGASTMLWGNAIFSLGAILVAAATTVRSFKFMIGGAVVQALGDVATQVAQYKIFSSWFPPSSGFASTLAFELGIGKIGSFVGKATANVIAQNLGDFSWAYWMAVFMNLFTNVATLFFWWFTRWCEKRYAGTKDPATGEKLTENNKKFEIGKMLSLPWSFWMVCLFSLFQTSTASVFASNSTELAEQRFKISAVKAGWYASMSQYLGFFFVPLIGVFVDMFGQRLTLMLVCGCGMLLSMCLVAWGPSVSGTAASFGIFAVATSFGPTVIIDSIRTSMWYQEVFGSGYAIKIAINNSMTIIVGVISGVIQDRNDNNYDNVTILYATMAAGSVVVGLIILALGYASDVMGHLQWSRKKRVENGHVIVAKKEEAESEGRAEWSRKLGMVNFGAVIVLILGAWVAYFWGLATKNTYK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PXXK01000635
EMBL· GenBank· DDBJ
RFN43185.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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