A0A395LXV8 · A0A395LXV8_9BACT

Function

function

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site79Zn2+ (UniProtKB | ChEBI)
Binding site266Zn2+ (UniProtKB | ChEBI)
Binding site270Zn2+ (UniProtKB | ChEBI)
Active site293Proton donor
Active site372

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Molecular Functionmetal ion binding
Molecular FunctionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Molecular FunctionUDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Processfatty acid biosynthetic process
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
  • EC number
  • Alternative names
    • (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
    • Beta-hydroxyacyl-ACP dehydratase
      ((3R)-hydroxymyristoyl-ACP dehydrase
      )
  • Recommended name
    UDP-3-O-acyl-N-acetylglucosamine deacetylase
  • EC number
  • Short names
    UDP-3-O-acyl-GlcNAc deacetylase
  • Alternative names
    • UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase

Gene names

    • Name
      fabZ
    • Synonyms
      lpxC
    • ORF names
      D0433_11310

Organism names

Accessions

  • Primary accession
    A0A395LXV8

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the LpxC family.
Belongs to the thioester dehydratase family. FabZ subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    477
  • Mass (Da)
    52,913
  • Last updated
    2018-12-05 v1
  • Checksum
    D677200EEAA580B6
MLAYQRTIKKEVSIWGRGLHTGQDCMITFKPAPEDYGYRFVRTDLPDSPEIPADIDHVIDIRRGTTIGIGDAKVHTTEHVLAALYGLQIDNCRIELTGPEPPVLDGSSKPFVDALLSAGFETQSAPKNYLVIEETVEYVDEARGVHIVGLPLDDFRATIMIDYKNPALGSQHTGIFDMEKEFASEFAGARTFCFLSEVAELARQGLIRGGDINNAIVIADCAMSQSELDELAQTLSGGKNNLRLEIGANGILNNRELRYPNEPARHKLLDLLGDLALIGMPIKAQILAARPGHAANVEFVKKLKKLIEKNKLTRRYQHERKAGVVFDAAAIQRILPHRYPFLLIDKILEFKLDEKIVAVKNVTLNEPFFQGHFPGNPIMPGVLILEAMAQSGGILLLNGNESFQDKDVFFMGIDHARFRKPVVPGDTLIIESVVKNRRRNVCRFSSQAFVRGELVCEAELMATVVPRQRSTSGYGAL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PHFL01000066
EMBL· GenBank· DDBJ
RFM23382.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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