A0A395HNL8 · A0A395HNL8_ASPHC
- ProteinDNA-directed RNA polymerase subunit
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2112 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Catalytic activity
- GTP + H2O = GDP + phosphate + H+
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial matrix | |
Cellular Component | RNA polymerase III complex | |
Molecular Function | DNA binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | ribosome binding | |
Molecular Function | RNA polymerase III activity | |
Biological Process | positive regulation of translation | |
Biological Process | translation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA-directed RNA polymerase subunit
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionA0A395HNL8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MRGCLQLARWLSAAPRCSA | ||||||
Chain | PRO_5017481961 | 20-2112 | DNA-directed RNA polymerase subunit | |||
Sequence: ASLLQPPFGLPTSVRFFANSAARSARGAGLQKSDLENRIAAIPIDRFRNFCIVAHVDHGKSTLSDRLLELTGTIQAGSNKQVLDKLDVERERGITVKAQTCTMLYNHNGEDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDASQGIQAQTVANFYLAFSQGLELIPVINKVDLPSAEPERALEQMKHSFELDTDSAVLVSAKTGLNVQQLLPTVVDRIPAPVGDHTKPLRMLLVDSWYDAYKGVICLVRVFDGEIRAGDQLVSFATGLKYFVGEVGIMYPNETPQTVLRAGQVGYVFFNPGMKRSKEAKIGDTYTKVGSEKLVEPLPGFEEPKSMVFVAAYPVDADHFEHLEDSINQLMLNDRSITVQKESSEALGAGFRLGFLGTLHCSVFEDRLRQEHGASIIITPPSVPVKIVYKDGREEIISNPAKFPDDESARAKVLEFHEPYVTATLTFPDEYLGKVIELCENNRGEQKSLEYFTSTQVILKYELPLAQLVDDFFGKLKGNTKGYASLDYEESAWRQSNIVKLQLLVNKAPVDAVARIVHYSQADRLGRQWVTKFKEHVDRQLFEVIIQAAIGRKVVARETVKPYRKDVLAKLHASDVSRRRKLLEKQKEGRKRLRAVGNVSLSPCHDHHLTTVMQPPEGVQVDLGKAQVIDRVPKVIKELKFGVLSNDDIVSQGVVEVSDRKFFDLEHDRAVVANGPLDARMGISNKSSTCQTCGGALQVCNGHFGHVRLVLPSFHVGYFKRVITILQEICKECSHILLPEADRRAFLREMRRPGLDNLRRMQIAKRINERCKKTRNCENCGAVNGVVKKAGTSALKITHDKFRAFNASTSVKKVPPPSKIVFDRSFDEARTSNAEVEKHYKKAQDDMNALRVLNLFKKISDTDCELLGLNPKEARPEMFLWQFIPAPPVCIRPSVGQDAASTEDDLTAKLGDIVQSNINLKNALLKGAPVQTIMECWDYMQLQIAVYINSDVPGLNKADLGKPIRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRVDEVAVPELVAKNMTYPEVVTRYNKEKLQQRVRNGTKKWPGANYITKKGQTFKLFLKYGNLNMIADQLQEGDVIERHIEDGDIVLFNRQPSLHKLSILSHFAKVRPHRTFRLNECVCNPYNADFDGDEMNLHVPQTEEARAEAMELMGVKNNLATPKNGEPIISAIQDFISAAYVLSSKDNFFDRRSFTQICLYMLGPQTRFDLPPPAVLKPQMLWTGKQVFNILMRPNKDDPCLVNLDAACREFKMPKDKTPKDLDPKDGWLVIRNSEVMCGVMDKSTIGSGKKDNVFYIMLRDFGPAAAAEGMNRLSKLSARWFTNMGFSIGITDVYPSEKLLRSKHDLVETAYAQCDEVIAKYKAGTLEKYPGCDELQTMENQLSGILSKVRQQAGDECIAQLSKYNSPLIMATSGSKGSSINVSQMVALVGQQIIGGQRVQDGFQDRTLPHFPKNARQPPSKGFVRNSFFSGLTPTEFIFHAMSGREGLVDTAVKTAETGYMSRRLMKSLEDLSTRYDDTVRNSSAAIVQFQYGDDKLDPVDMEGKAKPVHFDRTFIHSESITYSNDERSLLPAEIMEVCEEMLSKERAKLVRKDLMGNTLAYMDRSDHGIDQFESARDFLESIQQYVATKADRLISRGGDFDPSDERSQKGLNHTGKLTERTLRTFITECLMKYKKAQVEAGHAVGAVGAQSIGEPGTQMTLKTFHFAGVAGMSITQGVPRIKEIINASKEISTPVVACELVTKDNIIAARIVKGRIEQTYLRDIIHYIRETWTGKEAYITVKINWKTIQDLALELKIDNILAAIKSHKRFKADDLKFRCSRSHIHVYMDVEPSSKASLSKTEIAHTSADPFLRLKHLKRMLPDIQVLGHPQAYRAIIRTDETSTTNTLLVEGYGLRACMTTMGVDGLRTKTNNIMEMREVLGIEAARSTIVQEISEVMKDMDIDPRHMQLLADVMTYKGEVLGITRFGLAKMRDSVLQLASFEKTADHLFDAGGAGRTDLIEGVSECIIMGKTVSLGTGAMEVVRKMNFYEGQIGPRKTTFEDTWTDVYEAPLERARAKRKARA |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 64-244 | Tr-type G | ||||
Sequence: DRFRNFCIVAHVDHGKSTLSDRLLELTGTIQAGSNKQVLDKLDVERERGITVKAQTCTMLYNHNGEDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDASQGIQAQTVANFYLAFSQGLELIPVINKVDLPSAEPERALEQMKHSFELDTDSAVLVSAKTGLNVQQLLPTVVDRIPAPV | ||||||
Coiled coil | 876-903 | |||||
Sequence: FDEARTSNAEVEKHYKKAQDDMNALRVL |
Sequence similarities
Belongs to the GTP-binding elongation factor family. LepA subfamily.
Belongs to the RNA polymerase beta' chain family.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,112
- Mass (Da)236,227
- Last updated2018-12-05 v1
- ChecksumAC7E61DF7592B029
Keywords
- Technical term