A0A390ZIK4 · A0A390ZIK4_STAAU

  • Protein
    D-alanine--D-alanyl carrier protein ligase
  • Gene
    dltA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Pathway

Cell wall biogenesis; lipoteichoic acid biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site144-145ATP (UniProtKB | ChEBI)
Binding site189D-alanine (UniProtKB | ChEBI)
Binding site284-289ATP (UniProtKB | ChEBI)
Binding site293D-alanine (UniProtKB | ChEBI)
Binding site365ATP (UniProtKB | ChEBI)
Binding site473ATP (UniProtKB | ChEBI)
Binding site473D-alanine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionD-alanine [D-alanyl carrier protein] ligase activity
Biological Processlipoteichoic acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-alanine--D-alanyl carrier protein ligase
  • EC number
  • Short names
    DCL
  • Alternative names
    • D-alanine--poly(phosphoribitol) ligase subunit 1
    • D-alanine-activating enzyme
      (DAE
      )

Gene names

    • Name
      dltA
    • ORF names
      DQU50_00255
      , DQU51_12225
      , G0Z31_06260
      , G6Y24_10190
      , GQX52_01375
      , GZ111_003655
      , M1K003_2359
      , SAMEA70153168_01715

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • M1K003
    • Pt013
    • pt013
    • Pt014
    • pt014
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A390ZIK4
  • Secondary accessions
    • A0A4P7P4B9

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-342AMP-dependent synthetase/ligase
Domain395-473AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    485
  • Mass (Da)
    54,644
  • Last updated
    2018-12-05 v1
  • Checksum
    3E2DB528D8211794
MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNKQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEMCLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERLGARLSTTDDGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKVIHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIAEVING

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAIIGN010000005
EMBL· GenBank· DDBJ
CAC8239748.1
EMBL· GenBank· DDBJ
Genomic DNA
BDVT01000014
EMBL· GenBank· DDBJ
GBV21344.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAJIY010000014
EMBL· GenBank· DDBJ
NGK21119.1
EMBL· GenBank· DDBJ
Genomic DNA
JAALTR010000245
EMBL· GenBank· DDBJ
NGW67860.1
EMBL· GenBank· DDBJ
Genomic DNA
JAANDN010000012
EMBL· GenBank· DDBJ
NUY67318.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXH01000001
EMBL· GenBank· DDBJ
TXL38242.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXF01000001
EMBL· GenBank· DDBJ
TXL47542.1
EMBL· GenBank· DDBJ
Genomic DNA
CP152420
EMBL· GenBank· DDBJ
XAJ31120.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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