A0A389MLR9 · A0A389MLR9_9HYPH

  • Protein
    Bifunctional adenosylcobalamin biosynthesis protein
  • Gene
    cobU
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.
Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site13-20GTP (UniProtKB | ChEBI)
Binding site38-40GTP (UniProtKB | ChEBI)
Active site54GMP-histidine intermediate
Binding site85GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionadenosylcobinamide kinase (ATP-specific) activity
Molecular Functionadenosylcobinamide kinase (GTP-specific) activity
Molecular FunctionATP binding
Molecular Functioncobinamide phosphate guanylyltransferase activity
Molecular FunctionGTP binding
Biological Processcobalamin biosynthetic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional adenosylcobalamin biosynthesis protein
  • EC number

Gene names

    • Name
      cobU
    • ORF names
      AwMethylo_09710

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylobacteriaceae > Methylobacterium

Accessions

  • Primary accession
    A0A389MLR9

Proteomes

Family & Domains

Sequence similarities

Belongs to the CobU/CobP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    173
  • Mass (Da)
    18,654
  • Last updated
    2018-12-05 v1
  • MD5 Checksum
    C385716AAF7520AEFC48CA7473FF8813
MLVAPPRMTLVLGGARSGKSRYAEALIEAQPSPWLYLATGQAFDDEMRARIALHGERRRQGWRTLDVPLALPEAISDARGPVLVDCLTLWLTNLILSEAELEPAFGALLDACGAAPGPLVLVGNEVGLGIVPENALARRFRDEAGRLHQRLAAIADRVVLTVAGLPMTVKECR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BHEU01000006
EMBL· GenBank· DDBJ
GBU16756.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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