A0A388P6G6 · A0A388P6G6_9BACT
- ProteinMethionine synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids422 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
Catalytic activity
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
Cofactor
Protein has several cofactor binding sites:
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | cobalamin binding | |
Molecular Function | metal ion binding | |
Molecular Function | methionine synthase activity | |
Biological Process | homocysteine metabolic process | |
Biological Process | methylation | |
Biological Process | tetrahydrofolate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethionine synthase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Verrucomicrobiota > Opitutia
Accessions
- Primary accessionA0A388P6G6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-334 | Hcy-binding | ||||
Sequence: GERLEALLRQRIVYLDGAMGTMIQQLKLQEADYRGDRFKDHPGQLKGNNDLLVITKPAVVRDIHRAYLDAGADILETNTFNGTSIAMEDYAMTHLVRELNTEAVKVAREAVDAFKAANPGKDAFVAGAIGPTNKTLSMSRDVNDSAKRDVTFVQVRDSYREQVDALIDAGADLLLCETVFDTLVLKAALFAIDEAFEARGFRIPLMISGTITDASGRTLTGQTTEAFWNSVRHAQPLSVGMNCALGGEQMRPHIAELAKKADLFVSCYPNAGLPNPLSPTGFPEGPEDTAAILETFARDGLVNVLGGCCGTTPAHIAAIRRRT | ||||||
Domain | 366-422 | Pterin-binding | ||||
Sequence: FVNVGERTNVAGSKIFKGHIEKGDYRSALRVAKQQIEAGATIIDLTLTRGCSTALRR |
Sequence similarities
Belongs to the vitamin-B12 dependent methionine synthase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length422
- Mass (Da)45,558
- Last updated2018-12-05 v1
- ChecksumED9CA70EAF35675F