A0A388JUN4 · A0A388JUN4_CHABU
- ProteinEndonuclease/exonuclease/phosphatase domain-containing protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1247 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Probably binds two magnesium or manganese ions per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 558 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 630 | ||||
Active site | 660 | Proton donor/acceptor | |||
Binding site | 660 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 662 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Site | 662 | Transition state stabilizer | |||
Site | 719 | Important for catalytic activity | |||
Binding site | 743 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 744 | Proton acceptor | |||
Binding site | 744 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Site | 744 | Interaction with DNA substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | double-stranded DNA 3'-5' DNA exonuclease activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoric diester hydrolase activity | |
Biological Process | base-excision repair |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameEndonuclease/exonuclease/phosphatase domain-containing protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Charophyceae > Charales > Characeae > Chara
Accessions
- Primary accessionA0A388JUN4
Proteomes
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-20 | Disordered | |||
Region | 267-386 | Disordered | |||
Compositional bias | 271-288 | Polar residues | |||
Compositional bias | 349-371 | Polar residues | |||
Domain | 551-744 | Endonuclease/exonuclease/phosphatase | |||
Sequence similarities
Belongs to the DNA repair enzymes AP/ExoA family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,247
- Mass (Da)142,096
- Last updated2018-12-05 v1
- Checksum8DBC1813AF879150
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 271-288 | Polar residues | |||
Compositional bias | 349-371 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BFEA01000020 EMBL· GenBank· DDBJ | GBG61495.1 EMBL· GenBank· DDBJ | Genomic DNA |