A0A386R1F9 · A0A386R1F9_9CHON

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • G501
    • G502
    • G503
    • G504
    • G505
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Chondrichthyes > Elasmobranchii > Batoidea > Rajiformes > Rajidae > Raja

Accessions

  • Primary accession
    A0A386R1F9

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane26-56Helical
Transmembrane77-101Helical
Transmembrane121-144Helical
Transmembrane156-183Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-197Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    197
  • Mass (Da)
    20,959
  • Last updated
    2018-12-05 v1
  • Checksum
    D28660014C545E5B
LVGTGLSLLIRAELSQPGTLLGDDQIYNVIVTAHALVMIFFMVMPIMIGGFGNWLVPLMIGSPDMAFPRMNNMSFWLLPPSFLLLLASAGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILASINFITTIINMKPPAISQYQTPLFVWSILVTTVLLLMALPVLAAGITMLLTDRNLNTTFFDPAG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue197

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY949054
EMBL· GenBank· DDBJ
AYE56144.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949055
EMBL· GenBank· DDBJ
AYE56145.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949056
EMBL· GenBank· DDBJ
AYE56146.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949057
EMBL· GenBank· DDBJ
AYE56147.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949058
EMBL· GenBank· DDBJ
AYE56148.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949059
EMBL· GenBank· DDBJ
AYE56149.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949060
EMBL· GenBank· DDBJ
AYE56150.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949061
EMBL· GenBank· DDBJ
AYE56151.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949062
EMBL· GenBank· DDBJ
AYE56152.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949063
EMBL· GenBank· DDBJ
AYE56153.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949064
EMBL· GenBank· DDBJ
AYE56154.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949065
EMBL· GenBank· DDBJ
AYE56155.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949066
EMBL· GenBank· DDBJ
AYE56156.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949067
EMBL· GenBank· DDBJ
AYE56157.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949068
EMBL· GenBank· DDBJ
AYE56158.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949069
EMBL· GenBank· DDBJ
AYE56159.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949070
EMBL· GenBank· DDBJ
AYE56160.1
EMBL· GenBank· DDBJ
Genomic DNA
KY949071
EMBL· GenBank· DDBJ
AYE56161.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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