A0A386QWF1 · A0A386QWF1_9REOV

  • Protein
    Inner capsid protein VP2
  • Gene
    VP2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Inner capsid protein that self-assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels formed by VP2 N-termini. VP2 is required for the replicase activity of VP1 polymerase. Probably recruits a copy of a VP1-VP3 complex, potentially along with a segment of plus-strand RNA, as a decamer of VP2 assembles. May activate the autoinhibited VP1/RNA complex to coordinate packaging and genome replication.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site.

1887100200300400500600700800
TypeIDPosition(s)Description
Site231Interaction with the intermediate capsid protein VP6
Site235Interaction with the intermediate capsid protein VP6
Site846Interaction with the intermediate capsid protein VP6
Site848Interaction with the intermediate capsid protein VP6

GO annotations

AspectTerm
Cellular ComponentT=2 icosahedral viral capsid
Cellular Componentviral inner capsid
Cellular Componentviral nucleocapsid
Molecular FunctionRNA binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Inner capsid protein VP2

Gene names

    • Name
      VP2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BatRVA322/Taphozous mauritianus/KEN/Kwale/2015
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Duplornaviricota > Resentoviricetes > Reovirales > Sedoreoviridae > Rotavirus

Accessions

  • Primary accession
    A0A386QWF1

Subcellular Location

Virion
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

Keywords

PTM/Processing

Post-translational modification

Sumoylated with SUMO1 and SUMO2. Sumoylation of viral proteins seems to have a positive role on viral replication.

Keywords

Interaction

Subunit

Homodecamer; each decamer is made up of two conformers of VP2, called VP2A and VP2B. Interacts with a VP1-VP3 complex. Interacts with the intermediate capsid protein VP6. Interacts with NSP5. Interacts (via N-terminus) with NSP2.

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-30Basic and acidic residues
Region1-44Disordered
Region1-875-fold hub; involved in the encapsidation of VP1 and VP3
Region401-421Hydrophobic
Region429-449Hydrophobic

Domain

The N-terminus binds RNA. It is necessary for encapsidation of VP1 and VP3. The N-termini of 10 VP2 molecules form a cylindrical hub underneath each 5-fold axis of the inner capsid.

Sequence similarities

Belongs to the rotavirus VP2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    887
  • Mass (Da)
    103,275
  • Last updated
    2018-12-05 v1
  • Checksum
    007ADE64363BE3DF
MAYRKRGARRETILKQDDRMQEKEENKNVNSNIENKNATKTQLSEKVLSKKEEVITDNQEEIKIADEVKKSSKEESKQLLEVLKTKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQAKKQTKLFRIFEPKQLPIYRANGEKELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVIPNDMFIRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFVNNNQFRQVIIDGVLNQVLNDNIRNGHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYDYETLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDVSRVPDDQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQPVALVGALPFITDSSVISLIAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVPTSTTKVYKQVPQQFDFRASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-30Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH285827
EMBL· GenBank· DDBJ
AYE54340.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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