A0A386KZI3 · DABD_PSEMU

Function

function

Cytochrome P450 monooxygenase: part of the gene cluster that mediates the biosynthesis of domoic acid (DA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins causing amnesic shellfish poisoning (ASP) (PubMed:30262498).
Catalyzes the conversion of N-geranyl-L-glutamic acid (L-NGG) to N-(7'-carboxy-7'-demethylgeranyl)-L-glutamic acid (cNGG) via three successive steps involving N-(8'-hydroxygeranyl)-L-glutamic acid and N-(8'-oxogeranyl)-L-glutamic acid as intermediates (PubMed:30262498).

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Secondary metabolite biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site503Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionmonooxygenase activity
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Biological Processcellular response to carbon dioxide
Biological Processcellular response to phosphate starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-geranyl-L-glutamate oxidase
  • EC number
  • Alternative names
    • Domoic acid biosynthesis cluster protein D
      (PmDabD
      )

Gene names

    • Name
      dabD

Organism names

Accessions

  • Primary accession
    A0A386KZI3

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane49-71Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004542751-559N-geranyl-L-glutamate oxidase

Expression

Induction

Up-regulated under phosphate limitation and by increasing partial pressure of CO2.

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    559
  • Mass (Da)
    63,266
  • Last updated
    2018-12-05 v1
  • Checksum
    EAB402B04A884DA2
MNIATASLCAGLAVSGKFLSKYYQFLSTSQSDEVGFIEIMNMGMTGNDAVACASLGFVMYCVLSFARSYYRFRFSPLRNAPGFGPKSFVYGMFYEFLEAPFMEPPIEALKKLRKGGNDIPFLAYTTLFGSQRLLLLDCDLIKQVFTAPSGRDPMRYPKHYVYLREVVGDGLVVVEGSEWSRHRRIVQPAFQSAFLRDAITTTVPTLVENLVDVWKKTAGTSINLNAHLSIITLDVIGKVAFSHEFNASKLLNEWAECPDKELGEVDDPLISSIGAAFSSSPLKLMLTVLKQPWLEKHLSPAFRTSRNLLNKAADDIVQNAKNIDDPKRRSVLNLMMEAKDDESSKARNKLTDTELRDEVKTFLVAGHETTSTWAHWSLYVLATRPDIQEKVFADITKHSPDDKTILLEQADQMEYLWAFMNETLRLYSPLGLISRVTHKEENFKGYTIPAGTNLRIPIHLIHRHPDHWKDPEDFKPERWFDTEESSKRHKFAFIPFAAGGRNCIGQRFASMEAKIIVANVAKNFEIHLADSMKGKKITFSNFISLKCKPEIEIYVTPRG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH202990
EMBL· GenBank· DDBJ
AYD91074.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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