A0A385IUM5 · A0A385IUM5_LATMC

Function

function

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleotide binding
Biological ProcessGMP salvage
Biological Processguanine salvage
Biological Processhypoxanthine metabolic process
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hypoxanthine phosphoribosyltransferase
  • EC number

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Acropomatiformes > Lateolabracidae > Lateolabrax

Accessions

  • Primary accession
    A0A385IUM5

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain48-202Phosphoribosyltransferase

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    25,439
  • Last updated
    2018-12-05 v1
  • Checksum
    B2F258FC7AADAB70
MAGTDADMATPNPCVVISDEEQGYDLDLFCIPKHYATDLERVYIPHGLILDRTERLAREIMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGEIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMKTLLQLLKQYNPKMVKVASLLVKRTPRSVGYRPDFVGFEVPDKFVVGYALDYNEYFRDLNHICVISETGKEKYKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH181802
EMBL· GenBank· DDBJ
AXY87855.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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