A0A385IIU4 · A0A385IIU4_9CAUD
- ProteinSliding clamp
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids229 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Sliding clamp that encircles the genomic DNA and links the DNA polymerase to the template to control the processivity of DNA synthesis. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Interaction with the sliding-clamp-loader opens the sliding clamp so that it can be loaded around the DNA template. During transcription, encircles the DNA and tethers host RNA polymerase (RNAP) to it.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | DNA polymerase processivity factor activity | |
Biological Process | DNA replication | |
Biological Process | viral DNA genome replication | |
Biological Process | viral transcription |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSliding clamp
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Straboviridae > Twarogvirinae > Lazarusvirus > Lazarusvirus karl
Accessions
- Primary accessionA0A385IIU4
Proteomes
Interaction
Subunit
Homotrimer. Interacts with the viral DNA polymerase; this interaction constitutes the polymerase holoenzyme. Interacts with the sliding-clamp-loader; this interaction allows the sliding-clamp-loader to open the sliding clamp. Interacts with the viral DNA ligase. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the helicase and the helicase assembly factor. Interacts with the viral RNA polymerase (RNAP). Part of the transcription activation complex containing host RNAP, the viral RNA polymerase sigma-like factor, the late transcription coactivator, and the sliding clamp.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-109 | DNA polymerase processivity factor | ||||
Sequence: KFSKQFVSILKNFATINSGIYFQAGDFVMTRSASGATYGETTLPPGEEIEFNVAIYDLNAFLGILSLSGEDSEITSNGDEILIKGKRSVITWPAADPSAIVYPKKAIK | ||||||
Domain | 116-222 | Sliding clamp C-terminal | ||||
Sequence: EFDLSGDDYKQLMKISHGLGATTLTIENANGKVVFKTYNKEIDPNFEKPLSTFDVADYTGDKEFKFILHIQNMKLLPDDYKVKLWAVGEKFAVKFAGTQSSYVLSVE |
Sequence similarities
Belongs to the Tevenvirinae sliding clamp family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length229
- Mass (Da)25,319
- Last updated2018-12-05 v1
- Checksum46839C52C3A4AA04