A0A385IIU4 · A0A385IIU4_9CAUD

Function

function

Sliding clamp that encircles the genomic DNA and links the DNA polymerase to the template to control the processivity of DNA synthesis. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Interaction with the sliding-clamp-loader opens the sliding clamp so that it can be loaded around the DNA template. During transcription, encircles the DNA and tethers host RNA polymerase (RNAP) to it.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionDNA polymerase processivity factor activity
Biological ProcessDNA replication
Biological Processviral DNA genome replication
Biological Processviral transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sliding clamp
  • Alternative names
    • DNA polymerase accessory protein Gp45
    • DNA polymerase clamp

Gene names

    • ORF names
      KARL1_183

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Viruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Straboviridae > Twarogvirinae > Lazarusvirus > Lazarusvirus karl

Accessions

  • Primary accession
    A0A385IIU4

Proteomes

Interaction

Subunit

Homotrimer. Interacts with the viral DNA polymerase; this interaction constitutes the polymerase holoenzyme. Interacts with the sliding-clamp-loader; this interaction allows the sliding-clamp-loader to open the sliding clamp. Interacts with the viral DNA ligase. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, the primase, the helicase and the helicase assembly factor. Interacts with the viral RNA polymerase (RNAP). Part of the transcription activation complex containing host RNAP, the viral RNA polymerase sigma-like factor, the late transcription coactivator, and the sliding clamp.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-109DNA polymerase processivity factor
Domain116-222Sliding clamp C-terminal

Sequence similarities

Belongs to the Tevenvirinae sliding clamp family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    229
  • Mass (Da)
    25,319
  • Last updated
    2018-12-05 v1
  • Checksum
    46839C52C3A4AA04
MKFSKQFVSILKNFATINSGIYFQAGDFVMTRSASGATYGETTLPPGEEIEFNVAIYDLNAFLGILSLSGEDSEITSNGDEILIKGKRSVITWPAADPSAIVYPKKAIKFPEASVEFDLSGDDYKQLMKISHGLGATTLTIENANGKVVFKTYNKEIDPNFEKPLSTFDVADYTGDKEFKFILHIQNMKLLPDDYKVKLWAVGEKFAVKFAGTQSSYVLSVEDGSTHNF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH713599
EMBL· GenBank· DDBJ
AXY82802.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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