A0A385D3F3 · A0A385D3F3_9CAUD
- Proteinribonucleoside-triphosphate reductase (thioredoxin)
- Gene48
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids677 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- a 2'-deoxyribonucleoside 5'-triphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-triphosphate + [thioredoxin]-dithiol
CHEBI:61560 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 = CHEBI:61557 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 365 | |||||
Sequence: C | ||||||
Active site | 367 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | cobalamin binding | |
Molecular Function | nucleotide binding | |
Molecular Function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | |
Molecular Function | ribonucleoside-triphosphate reductase (thioredoxin) activity | |
Biological Process | DNA replication |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameribonucleoside-triphosphate reductase (thioredoxin)
- EC number
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Backyardiganvirus > Backyardiganvirus peaches
Accessions
- Primary accessionA0A385D3F3
Proteomes
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 89↔376 | Redox-active | ||||
Sequence: CWVSGWTEKPSDHFEFTFMRLMEGGGVGANYSNRFIDYGPVPQELYVHIVCDEEHPDYQAMKDAGVLSTEYDPEWAGAFVIEDSREGWAAALVDLIDTHYRDEVSHFQRVYDVSRVRPFGAKLKTFGGRASGPLPLARMLIDVCEVLSEIATVGGSLNGIAAMEIDHAIAQCVVAGGVRRSARMSMMHWQDPQIEEFVRCKQETGKHWTTNISVVVDDLFWTALNMPNQVSIMVRDQAHKALKWITDGMVANGEPGFWDSSLSNQGEPNEVVCTNPCGEITLQEWEPC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-79 | Ribonucleotide reductase alpha helical | ||||
Sequence: NWGPTGEIVYNRTYSRVKPDGSSETWPETVERVVDGNLALVDARYRQPGEREELIRLITEFKMLPAGRHLWASG | ||||||
Domain | 136-235 | B12-dependent ribonucleotide reductase insertion | ||||
Sequence: HIVCDEEHPDYQAMKDAGVLSTEYDPEWAGAFVIEDSREGWAAALVDLIDTHYRDEVSHFQRVYDVSRVRPFGAKLKTFGGRASGPLPLARMLIDVCEVL | ||||||
Domain | 237-321 | Ribonucleotide reductase large subunit C-terminal | ||||
Sequence: EIATVGGSLNGIAAMEIDHAIAQCVVAGGVRRSARMSMMHWQDPQIEEFVRCKQETGKHWTTNISVVVDDLFWTALNMPNQVSIM | ||||||
Domain | 329-454 | Ribonucleotide reductase large subunit C-terminal | ||||
Sequence: ALKWITDGMVANGEPGFWDSSLSNQGEPNEVVCTNPCGEITLQEWEPCNLGHINLAAFVKDNGKVDTIDLIRSHRLMARFLIRATFSPVGDPKSREVLDRNRRIGVGHLGVASYLAMTGRRYSKAP | ||||||
Domain | 491-610 | Ribonucleotide reductase large subunit C-terminal | ||||
Sequence: TVAPTGTIAKMPGVSEGIHPIFAKYFYRRIRFSKGDPQIEELREQGYEVEDDLYAQNTVVVTIPTKDTLVQEVVDRFGRDAEEIVESAEDLTLNQLLAFQAMYQMLWADNAVSFTANVDP |
Sequence similarities
Belongs to the class II ribonucleoside-triphosphate reductase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length677
- Mass (Da)76,036
- Last updated2018-12-05 v1
- Checksum8A966DC6545FD12C