A0A385AJN0 · TPS11_DICPU
- ProteinTerpene synthase 11
- GeneTPS11
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids325 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpenes (E)-beta-farnesene and (E,E)-alpha-farnesene (PubMed:30254228).
TPS11 also converts geranylgeranyl diphosphate (GGPP) into the diterpene (S)-nephthenol (PubMed:31621716).
TPS11 also converts geranylgeranyl diphosphate (GGPP) into the diterpene (S)-nephthenol (PubMed:31621716).
Catalytic activity
- (2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphateThis reaction proceeds in the forward direction.
- geranylgeranyl diphosphate + H2O = (S)-+-nephthenol + diphosphateThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | lyase activity | |
Molecular Function | metal ion binding | |
Biological Process | isoprenoid biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTerpene synthase 11
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionA0A385AJN0
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000457028 | 1-325 | Terpene synthase 11 | |||
Sequence: MDINKQKTKWDISIFKNENFTLPVIKSPFNTYYNKYIDSVINDIEEWHRECCFLGREKLKGYIESKPYLFSAYYYCHLNEKVLPFIIKFVDMFSIYDDEYLEKTNCSEDVINQFLDKNYKDKNIYGVEWFKIVEGLKKYGNKQSVNKFLKEFEFFIKNVHSIHLKENANYTNINFEEYTNTRSIDFGFDLVVSAAIIDCEEPSKEIRESSLFLTLNTKSSIICVLVNDIYSFVKESKQPDTMNYVKIMANKKKSIQKALNHTNKIINNTLKEIISIENQIKMQYKENNLYQYIERLNSVISATIYLHQNHKRYSVHNKNYINKNN |
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 97-102 | DDxx(x)D/E motif | ||||
Sequence: DDEYLE | ||||||
Motif | 227-235 | NDxxSxxxD/E motif | ||||
Sequence: NDIYSFVKE |
Domain
Contains several highly conserved motifs that are important for catalytic activity including the aspartate-rich 'DDxx(x)D/E' motif and the 'NDxxSxxxD/E' motif, both of which are involved in complexing metal ions to coordinate the binding of the isoprenyl diphosphate substrate in the active site.
Sequence similarities
Belongs to the terpene synthase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length325
- Mass (Da)38,767
- Last updated2018-12-05 v1
- Checksum07C53ACA5CF776F3
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MG262472 EMBL· GenBank· DDBJ | AXN72980.1 EMBL· GenBank· DDBJ | mRNA | ||
GL871106 EMBL· GenBank· DDBJ | EGC34225.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |