A0A384VAK4 · A0A384VAK4_9ALPC
- ProteinORF1ab polyprotein
- GeneORF1b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2678 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 1610 | ||||
Active site | 1612 | ||||
Active site | 1711 | ||||
Active site | 1787 | ||||
Active site | 1792 | ||||
Binding site | 1850-1856 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Active site | 2265 | ||||
Active site | 2280 | ||||
Active site | 2321 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell perinuclear region of cytoplasm | |
Cellular Component | membrane | |
Molecular Function | 3'-5'-RNA exonuclease activity | |
Molecular Function | 5'-3' DNA helicase activity | |
Molecular Function | ATP binding | |
Molecular Function | endonuclease activity | |
Molecular Function | mRNA (nucleoside-2'-O-)-methyltransferase activity | |
Molecular Function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity | |
Molecular Function | peptidase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | viral translational frameshifting |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameORF1ab polyprotein
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Alphacoronavirus > Tegacovirus > Alphacoronavirus 1
Accessions
- Primary accessionA0A384VAK4
Subcellular Location
UniProt Annotation
GO Annotation
Host membrane ; Multi-pass membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-249 | NiRAN | |||
Domain | 255-353 | Nsp12 Interface | |||
Domain | 354-921 | Nsp12 RNA-dependent RNA polymerase | |||
Domain | 922-1005 | CV ZBD | |||
Domain | 1169-1530 | +RNA virus helicase C-terminal | |||
Domain | 1592-1806 | ExoN | |||
Domain | 1815-2036 | N7-MTase | |||
Region | 1927-1941 | GpppA-binding | |||
Domain | 2040-2100 | Nsp15 N-terminal oligomerization | |||
Domain | 2101-2218 | AV-Nsp11N/CoV-Nsp15M | |||
Domain | 2235-2375 | NendoU | |||
Domain | 2379-2675 | Nidovirus-type SAM-dependent 2'-O-MTase | |||
Sequence similarities
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,678
- Mass (Da)302,923
- Last updated2018-12-05 v1
- ChecksumAF261A25F98A2932
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Keywords
- Coding sequence diversity
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KX900411 EMBL· GenBank· DDBJ | ASV64437.1 EMBL· GenBank· DDBJ | Genomic RNA |