A0A384L1A0 · A0A384L1A0_PLAKH

Function

function

RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N4-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site386-395ATP (UniProtKB | ChEBI)
Binding site565ATP (UniProtKB | ChEBI)
Binding site815-821acetyl-CoA (UniProtKB | ChEBI)
Binding site895acetyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Component90S preribosome
Cellular Componentnucleolus
Molecular FunctionATP binding
Molecular FunctionrRNA cytidine N-acetyltransferase activity
Molecular FunctiontRNA binding
Molecular FunctiontRNA N-acetyltransferase activity
Biological ProcessrRNA acetylation involved in maturation of SSU-rRNA
Biological ProcesstRNA acetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA cytidine acetyltransferase
  • EC number
  • Alternative names
    • 18S rRNA cytosine acetyltransferase

Gene names

    • ORF names
      PKNH_0604900

Organism names

  • Taxonomic identifier
  • Strain
    • H
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    A0A384L1A0
  • Secondary accessions
    • A0A1A7VPR1
    • B3L1W5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain8-199tRNA(Met) cytidine acetyltransferase TmcA N-terminal
Region285-325Disordered
Compositional bias288-317Basic and acidic residues
Domain381-583Helicase
Domain623-686N-acetyltransferase
Region704-777Disordered
Compositional bias716-738Acidic residues
Compositional bias739-759Basic and acidic residues
Domain774-833N-acetyltransferase
Domain870-923N-acetyltransferase
Domain1018-1183Possible tRNA binding

Sequence similarities

Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,208
  • Mass (Da)
    140,162
  • Last updated
    2018-11-07 v1
  • Checksum
    6279084E3EC3940A
MKKKVDGRIKTLVENNVALGQRSMFLVVGDQGKNVVVNFYFLLNRLASRTHKILWCYKKKLEFSTSKKKRFREMKKKIKKGTFDTTIDNHFDAFLKSANIRFCFYNETKKVLGKTYSMCVLQDFSYITPNILCRCIETVIGGGIILFLLNKLDDVKNIYNITLNCHKKYTQSGISSVYNNYITRFFLSLNECSNAMFIDDEMNILPLNDNHLHVKKLVVEERQEGDVSVNASRAATLGGYLCPDKEELRERLAQLEAICDENERKAEEHRRFLYSARVFAGGEGLEGKKTNRQTDKHGIDKHGIEKHGTDKHGTDKQVQGQIESAGTDEQTNQYSFLNRPIMNLLRICLTIDQLEVLLNMCKILRNDEEKKRQLKEVLINLLANRGRGKSATLGLLIALSIYFNYTNVILCSGNNDGMQTIYEFIDQGLHLLGYKEFSHYERIQNQGKLKEIIVFKDIHNLSNVKQRIRYFDILEEDMVNSELMIIDEAACIPIDILRGKIKGEITILSTTLNGYEGTGKTFIFKLLKQLKKKFVTQLSYGDFKKMKRLYFERAFIDISLGTPIRYSYNDQVEAWLNNFLCLNCNEPFKLKNSLCSPVNCQLYLVNKNIFKRFTKTSENFLKKIMVLFVTSHYKNTPNDLIMILDSQQHHLFVLLSGNVDCNNLSAEAVDELDIYGVLHCAIDGIVHPPAGRRLVKLQDLTKGGEKHSQVDEQVDSQADEQMDEQVDEQVDEQMDEQMEEQVNGERNGDYFKQGGKPSDDRTGGETANPTTEKHSMPKEFEGNLMPYLVTEHFDYYFYNYIGIRVVRISIHPSIQNLNYGSQFLRKLFDYYSLYNGRRGREAGVPYRENVILYRCSGDGGEGADGRIFFDKQLSHVDYVGTCFGLTKGLLIFWQKNNFIPVYLKQQRNEITGEFSLLMLRHLNVNLKKVFTNFYLDFVRSFCSLLPYSFRRLESFVVFNLLHNNPIVLTNPTRDELLLPREKGKEIEKEVNVDVEEEKGLLSLPDEDGDQYACFYDDELLSQENLFYFFHPNDICRLKRFVMEAKPFADILYLMQTVANLILFRKVPIQLTFLEYTILYAVSLQKKNTQEISNEISIHVNQTIALLRKVLHRFYTYLKDLMQRDIEKKVEAQFSQKLHKKKKRARQVELPSEEYIDELNRNTRVVTKKNKKEKRALLREFNLSGTVRRKQINIKTNDGADPAKDKVTS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias288-317Basic and acidic residues
Compositional bias716-738Acidic residues
Compositional bias739-759Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM910988
EMBL· GenBank· DDBJ
CAA9987099.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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