A0A384KX72 · A0A384KX72_PLAKH

Function

function

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenteukaryotic 43S preinitiation complex
Cellular Componenteukaryotic 48S preinitiation complex
Cellular Componenteukaryotic translation initiation factor 3 complex, eIF3e
Cellular Componenteukaryotic translation initiation factor 3 complex, eIF3m
Cellular Componentmulti-eIF complex
Molecular FunctionmRNA binding
Molecular Functiontranslation initiation factor activity
Biological Processformation of cytoplasmic translation initiation complex
Biological Processtranslation reinitiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Eukaryotic translation initiation factor 3 subunit A
  • Short names
    eIF3a
  • Alternative names
    • Eukaryotic translation initiation factor 3 subunit 10

Gene names

    • ORF names
      PKNH_1432100

Organism names

  • Taxonomic identifier
  • Strain
    • H
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    A0A384KX72
  • Secondary accessions
    • A0A1A7VGZ8
    • B3LCC3

Proteomes

Organism-specific databases

Interaction

Subunit

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

Type
IDPosition(s)Description
Region274-345Disordered
Compositional bias282-327Basic and acidic residues
Compositional bias333-345Basic and acidic residues
Domain415-595PCI
Coiled coil700-774
Region948-976Disordered
Region1015-1083Disordered
Compositional bias1095-1192Basic and acidic residues
Region1095-1270Disordered
Compositional bias1199-1262Basic and acidic residues

Sequence similarities

Belongs to the eIF-3 subunit A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,283
  • Mass (Da)
    154,074
  • Last updated
    2018-11-07 v1
  • MD5 Checksum
    6F51D68C3FE961C9CFE7293EC9258CE0
MQTFQKPENALKRAEELQFIGQNEDALQILHAAIGHRTFRLQGWHILQEQIMLRYIEFCLYLEKLSLVKDGLHQYRIICQHGNIASLGKVITDFRDKAEEKVRLAKENVNLNKEKIEQDESNVDFTEKILISSLDIEIAGKYERKLQNAFRICMETYKMILEILRATPKLEKAYHETAKKALIFCKENKRLTEFKKLSDLLRNHYNLILRGKHKPEYQSLLKIEYHLETKIIQLETACELGMWKEASNIAEDIYNLNMHDYFYRTLRANLVESEASGAGESSTRKADKEKGQLKSDGKESSKKGKDESKQGEDVEEDSSKVEKKDGTMEETEKDGANETKDNKVEGAHTVIHVNESSGNVNYALAKSRDNLKNWVGTFYQRMAEILFVYESELFHGLAWLKYCFHILNYSKNIPEKEKTFICTKAVLAVISIPLVGNKKKNEDYAKIFEAHKKMSQLLGHTSVPIKESLKNGLKVRNILNYADENAQKLYSLMENQFTPLSLCLECDVLLKELEATEHSVYISKIKEVIFHKLILQLSKVYSHISIDYFIENICPESFISWNEAETMLVDLVYQKELEMRIDLIKRAIYFGDKENTNSSKLIKESLTNLYYELQTGLKIMNETISIENEVEHLHMKKLTYEKEFDMLDRAHHKIMNYETANIEDVIENEVFEDKPIEDEKMLKKIYDKIDEEHHKFQLLSEENSRKRKELLRKQKELEQAQLKLKMEKKLLEEKLEKEKREELAKKGEKLRIKEEKTKKKSEAAEQMLKEIKKLCTNNTGKILMKGKYLDEITIEDILNGYVDFEDIEEAQEKLRLNERNEIIKVRKMEYKKVDHYFRALRQVELSHMNKWIALVFQEDTEILLQEQKAAEEEQKADFEAALKEKEEYVKFSNDIEEFTKSEMKDRIVEFEKNLKDQKDRLHQLLKDEKIQRAKERREQHLRKLKAEEERKRREEEEERLMKEEMERKKKEEAHRKKLDEISRIQRERDLEIEQQLLKRKEESRIGDKYYRKPSYEDDFSWKRGDKAGSQHDEDSNYKRLDDAQDSSYIDRSDRRERRDWPGRDRERERDRERDRDRERERERDRDRIFRKDRDYRRDRSKDRERERSRDRDREYRKERDYRGDRDREYRSYRDKERDRDRDYRRDRDRDYRRDDDYRRDRDYKNDRDDKLDRDYRKVERSGKGEHERRRDRDEEEYERNDLDVKKNHNIHDEDDSVRVEKGKEGHSGNDSDGANHHHLKEKEKMTNGKDITKNEQAKHEEASDGGGDFTVFKKKKRGFMKFF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias282-327Basic and acidic residues
Compositional bias333-345Basic and acidic residues
Compositional bias1095-1192Basic and acidic residues
Compositional bias1199-1262Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM910996
EMBL· GenBank· DDBJ
CAA9990919.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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