A0A384KR22 · A0A384KR22_ARATH

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site81-84substrate
Binding site103substrate
Binding site104Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity
Molecular Functionribonuclease inhibitor activity
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase

Gene names

    • ORF names
      AN1_LOCUS22422
      , AT9943_LOCUS19306
      , C24_LOCUS22313
    • Ordered locus names
      AXX17_At5g16040

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Landsberg erecta
    • cv. An-1
    • cv. C24
    • cv. Cdm-0
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    A0A384KR22

Proteomes

Genome annotation databases

Expression

Gene expression databases

Interaction

Subunit

Homotrimer.

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    166
  • Mass (Da)
    17,820
  • Last updated
    2018-11-07 v1
  • Checksum
    5386A92A2C0F2229
MAFVTTAEVCDANQELIRSGQLRALQPIFQIYGRRQIFSGPVVTVKVFEDNGLIRQFIEEKGNGRVLVVDGGGSQRCAILGGNPVVQAQNNGWAGIVVNGCIRDVDEINGCDIGVRALASHPIKASKKGLGEQRVPVNIAGTRICDGEWLYADTDGILVSQIELSV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CACSHJ010000096
EMBL· GenBank· DDBJ
CAA0402990.1
EMBL· GenBank· DDBJ
Genomic DNA
LR881470
EMBL· GenBank· DDBJ
CAD5331861.1
EMBL· GenBank· DDBJ
Genomic DNA
LUHQ01000005
EMBL· GenBank· DDBJ
OAO95374.1
EMBL· GenBank· DDBJ
Genomic DNA
CACRSJ010000110
EMBL· GenBank· DDBJ
VYS67020.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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