A0A384KR22 · A0A384KR22_ARATH
- Protein4-hydroxy-4-methyl-2-oxoglutarate aldolase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids166 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
Catalytic activity
- 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxaloacetate decarboxylase activity | |
Molecular Function | ribonuclease inhibitor activity | |
Biological Process | regulation of RNA metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-4-methyl-2-oxoglutarate aldolase
- EC number
- Short namesHMG aldolase
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionA0A384KR22
Proteomes
Genome annotation databases
Expression
Gene expression databases
Interaction
Subunit
Homotrimer.
Structure
Sequence
- Sequence statusComplete
- Length166
- Mass (Da)17,820
- Last updated2018-11-07 v1
- Checksum5386A92A2C0F2229
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CACSHJ010000096 EMBL· GenBank· DDBJ | CAA0402990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR881470 EMBL· GenBank· DDBJ | CAD5331861.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LUHQ01000005 EMBL· GenBank· DDBJ | OAO95374.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACRSJ010000110 EMBL· GenBank· DDBJ | VYS67020.1 EMBL· GenBank· DDBJ | Genomic DNA |