A0A384KQK8 · A0A384KQK8_HPV16

Function

function

Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.

Miscellaneous

Belongs to the high risk human alphapapillomavirus family. The cancer-causing human papillomavirus E6 protein has a unique carboxy terminal PDZ domain containing substrate.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular FunctionPDZ domain binding
Biological ProcessDNA-templated transcription
Biological Processregulation of DNA-templated transcription
Biological Processsymbiont-mediated perturbation of host apoptosis
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein E6

Gene names

    • Name
      E6

Organism names

  • Taxonomic identifier
  • Strains
    • Qv15521E
    • Qv17722E
    • CU1
    • CU4
    • CU5
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Zurhausenvirales > Papillomaviridae > Firstpapillomavirinae > Alphapapillomavirus > Alphapapillomavirus 9

Accessions

  • Primary accession
    A0A384KQK8

Proteomes

Subcellular Location

Keywords

Expression

Keywords

Interaction

Subunit

Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP and thus forms a complex with human TP53. Interacts with human NFX1 and MAGI3. Interacts with human IRF3; this interaction inhibits the establishment of antiviral state. Interacts with human TYK2; this interaction inhibits JAK-STAT activation by interferon alpha. Interacts with host DLG1; this interaction leads to the proteasomal degradation of DLG1.

Structure

3D structure databases

Family & Domains

Features

Showing features for zinc finger, motif.

Type
IDPosition(s)Description
Zinc finger37-73
Zinc finger110-146
Motif156-158PDZ-binding domain

Sequence similarities

Belongs to the papillomaviridae E6 protein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    158
  • Mass (Da)
    19,187
  • Last updated
    2018-11-07 v1
  • Checksum
    01FEF5ADCFDB37EB
MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY686581
EMBL· GenBank· DDBJ
AAV91660.1
EMBL· GenBank· DDBJ
Genomic DNA
AY686584
EMBL· GenBank· DDBJ
AAV91684.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ610146
EMBL· GenBank· DDBJ
ACS92644.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ610149
EMBL· GenBank· DDBJ
ACS92668.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ610150
EMBL· GenBank· DDBJ
ACS92676.1
EMBL· GenBank· DDBJ
Genomic DNA
KP212150
EMBL· GenBank· DDBJ
ALB35229.1
EMBL· GenBank· DDBJ
Genomic DNA
KP212151
EMBL· GenBank· DDBJ
ALB35237.1
EMBL· GenBank· DDBJ
Genomic DNA
KP212152
EMBL· GenBank· DDBJ
ALB35245.1
EMBL· GenBank· DDBJ
Genomic DNA
KP212153
EMBL· GenBank· DDBJ
ALB35253.1
EMBL· GenBank· DDBJ
Genomic DNA
KP212157
EMBL· GenBank· DDBJ
ALB35285.1
EMBL· GenBank· DDBJ
Genomic DNA
KP874716
EMBL· GenBank· DDBJ
ALB35309.1
EMBL· GenBank· DDBJ
Genomic DNA
KP874717
EMBL· GenBank· DDBJ
ALB35316.1
EMBL· GenBank· DDBJ
Genomic DNA
KP874719
EMBL· GenBank· DDBJ
ALB35330.1
EMBL· GenBank· DDBJ
Genomic DNA
KU298880
EMBL· GenBank· DDBJ
ALT54587.1
EMBL· GenBank· DDBJ
Genomic DNA
KU298881
EMBL· GenBank· DDBJ
ALT54595.1
EMBL· GenBank· DDBJ
Genomic DNA
KU298882
EMBL· GenBank· DDBJ
ALT54603.1
EMBL· GenBank· DDBJ
Genomic DNA
KU298885
EMBL· GenBank· DDBJ
ALT54627.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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