A0A384KQC4 · A0A384KQC4_HALVD

Function

function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site9-14NAD+ (UniProtKB | ChEBI)
Binding site91-93NAD+ (UniProtKB | ChEBI)
Binding site115-118NAD+ (UniProtKB | ChEBI)
Active site147Proton donor/acceptor
Binding site148(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)
Active site151Proton donor
Binding site157-158(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate reductase
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate reductase
  • EC number
  • Short names
    HTPA reductase

Gene names

    • Name
      dapB
    • ORF names
      C498_13254

Organism names

Accessions

  • Primary accession
    A0A384KQC4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain4-118Dihydrodipicolinate reductase N-terminal
Domain121-252Dihydrodipicolinate reductase C-terminal
Region172-191Disordered

Sequence similarities

Belongs to the DapB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    253
  • Mass (Da)
    26,062
  • Last updated
    2018-11-07 v1
  • Checksum
    82A5E76A933E03D7
MTVSVGVTGATGRMGGEVLAAAADRDDLSVAFAVSRSPGDVVEGVAVEDAADFADLLASHEPDVVVDFTGPASCIEYASACAAAGVAFVTGTTGLSEGGFDALREAASEAPVLYASNFSRGIAALRRAVREAVPALDGYDIELTETHHNAKRDAPSGTALTLLDDIDDVRGDSERVHGREGDAPRSEGEVGVHARRAGDIAGEHEVLLAGNHESLSLTHRAGSRGVFAAGALDAAAWLADRDAGWYDFTEVLE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AOHU01000092
EMBL· GenBank· DDBJ
ELY27512.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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