Transmembrane signaling by the alpha subunit of the type I interferon receptor is essential for activation of the JAK kinases and the transcriptional factor ISGF3.Colamonici O.R., Platanias L.C., Domanski P., Handa R., Gilmour K.C., Diaz M.O., Reich N., Pitha-Rowe P.View abstractCategoriesFunction, Sequences, ExpressionSourceMGI: 107658PubMedEurope PMCJ Biol Chem 270:8188-8193 (1995)Mapped to17
A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.Hwang S.Y., Hertzog P.J., Holland K.A., Sumarsono S.H., Tymms M.J., Hamilton J.A., Whitty G., Bertoncello I., Kola I.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCProc Natl Acad Sci U S A 92:11284-11288 (1995)Mapped to8
Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses.Deng S., He W., Gong A.Y., Li M., Wang Y., Xia Z., Zhang X.T., Huang Pacheco A.S., Naqib A.[...], Chen X.M.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCNat Commun 14:1456-1456 (2023)Mapped to8
Interferon partly dictates a divergent transcriptional response in poxvirus-infected and bystander inflammatory monocytes.Melo-Silva C.R., Roman M.I., Knudson C.J., Tang L., Xu R.H., Tassetto M., Dolan P., Andino R., Sigal L.J.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCCell Rep 41:111676-111676 (2022)Mapped to13
Zika virus vertical transmission in interferon receptor1-antagonized Rag1<sup>-/-</sup> mice results in postnatal brain abnormalities and clinical disease.Winkler C.W., Clancy C.S., Rosenke R., Peterson K.E.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCActa Neuropathol Commun 10:46-46 (2022)Mapped to27
Lung type II alveolar epithelial cells collaborate with CCR2<sup>+</sup> inflammatory monocytes in host defense against poxvirus infection.Yang N., Luna J.M., Dai P., Wang Y., Rice C.M., Deng L.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCNat Commun 13:1671-1671 (2022)Mapped to43
Regulation of MHC Class I Expression in Lung Epithelial Cells during Inflammation.Mathe J., Benhammadi M., Kobayashi K.S., Brochu S., Perreault C.View abstractCategoriesExpressionSourceMGI: 107658PubMedEurope PMCJ Immunol 208:1021-1033 (2022)Mapped to38
Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice.Allred M.G., Chimenti M.S., Ciecko A.E., Chen Y.G., Lieberman S.M.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCInt J Mol Sci 22:3767-3767 (2021)Mapped to23
Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice.Stutte S., Ruf J., Kugler I., Ishikawa-Ankerhold H., Parzefall A., Marconi P., Maeda T., Kaisho T., Krug A.[...], Brocker T.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCBrain Behav Immun 95:429-443 (2021)Mapped to12
Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.Papaioannou N.E., Salei N., Rambichler S., Ravi K., Popovic J., Kuntzel V., Lehmann C.H.K., Fiancette R., Salvermoser J.[...], Schraml B.U.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCNat Commun 12:464-464 (2021)Mapped to35
Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice.Debreceni I.L., Chimenti M.S., Serreze D.V., Geurts A.M., Chen Y.G., Lieberman S.M.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCInt J Mol Sci 21:E9478-E9478 (2020)Mapped to17
Transient microglial absence assists postmigratory cortical neurons in proper differentiation.Hattori Y., Naito Y., Tsugawa Y., Nonaka S., Wake H., Nagasawa T., Kawaguchi A., Miyata T.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCNat Commun 11:1631-1631 (2020)Mapped to62
IL-36 promotes anti-viral immunity by boosting sensitivity to IFN- alpha/beta in IRF1 dependent and independent manners.Wang P., Gamero A.M., Jensen L.E.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCNat Commun 10:4700-4700 (2019)Mapped to38
Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection.Bradley K.C., Finsterbusch K., Schnepf D., Crotta S., Llorian M., Davidson S., Fuchs S.Y., Staeheli P., Wack A.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCCell Rep 28:245-256.e4 (2019)Mapped to19
Interferon-lambda modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.Hemann E.A., Green R., Turnbull J.B., Langlois R.A., Savan R., Gale M. Jr.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCNat Immunol 20:1035-1045 (2019)Mapped to18
Organ-Specific Expression of IL-1 Receptor Results in Severe Liver Injury in Type I Interferon Receptor Deficient Mice.Anzaghe M., Resch T., Schaser E., Kronhart S., Diez C., Niles M.A., Korotkova E., Schulke S., Wolfheimer S.[...], Waibler Z.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCFront Immunol 10:1009-1009 (2019)Mapped to12
Zika virus infects human testicular tissue and germ cells.Matusali G., Houzet L., Satie A.P., Mahe D., Aubry F., Couderc T., Frouard J., Bourgeau S., Bensalah K.[...], Dejucq-Rainsford N.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCJ Clin Invest 128:4697-4710 (2018)Mapped to8
IFNAR1 Controls Autocrine Type I IFN Regulation of PD-L1 Expression in Myeloid-Derived Suppressor Cells.Xiao W., Klement J.D., Lu C., Ibrahim M.L., Liu K.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCJ Immunol 201:264-277 (2018)Mapped to10
Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.Gopinath S., Kim M.V., Rakib T., Wong P.W., van Zandt M., Barry N.A., Kaisho T., Goodman A.L., Iwasaki A.View abstractCategoriesFunction, Expression, Phenotypes & VariantsSourceMGI: 107658PubMedEurope PMCNat Microbiol 3:611-621 (2018)Mapped to71
Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages.Dabitao D., Hedrich C.M., Wang F., Vacharathit V., Bream J.H.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCJ Immunol 200:2154-2164 (2018)Mapped to30
Type I interferons instigate fetal demise after Zika virus infection.Yockey L.J., Jurado K.A., Arora N., Millet A., Rakib T., Milano K.M., Hastings A.K., Fikrig E., Kong Y.[...], Iwasaki A.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCSci Immunol 3:eaao1680-eaao1680 (2018)Mapped to22
IFN-lambda suppresses intestinal inflammation by non-translational regulation of neutrophil function.Broggi A., Tan Y., Granucci F., Zanoni I.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCNat Immunol 18:1084-1093 (2017)Mapped to10
Ischemia/Reperfusion Induces Interferon-Stimulated Gene Expression in Microglia.McDonough A., Lee R.V., Noor S., Lee C., Le T., Iorga M., Phillips J.L.H., Murphy S., Moller T., Weinstein J.R.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCJ Neurosci 37:8292-8308 (2017)Mapped to14
T Cell-Derived IL-10 Impairs Host Resistance to <i>Mycobacterium tuberculosis</i> Infection.Moreira-Teixeira L., Redford P.S., Stavropoulos E., Ghilardi N., Maynard C.L., Weaver C.T., Freitas do Rosario A.P., Wu X., Langhorne J., O'Garra A.View abstractCategoriesFunction, ExpressionSourceMGI: 107658PubMedEurope PMCJ Immunol 199:613-623 (2017)Mapped to20
Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome.Ghazarian M., Revelo X.S., Nohr M.K., Luck H., Zeng K., Lei H., Tsai S., Schroer S.A., Park Y.J.[...], Winer D.A.View abstractCategoriesFunction, Expression, Phenotypes & VariantsSourceMGI: 107658PubMedEurope PMCSci Immunol 2:eaai7616-eaai7616 (2017)Mapped to16