A0A384D762 · A0A384D762_URSMA
- ProteinPhosphodiesterase
- GenePDE1B
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids524 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 211 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 211-215 | AMP (UniProtKB | ChEBI) | ||||
Sequence: HNQIH | ||||||
Binding site | 215 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 251 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 252 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 252 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 252 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 358 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 358 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 409 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | neuronal cell body | |
Molecular Function | calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | cellular response to granulocyte macrophage colony-stimulating factor stimulus | |
Biological Process | cellular response to macrophage colony-stimulating factor stimulus | |
Biological Process | dopamine catabolic process | |
Biological Process | locomotory behavior | |
Biological Process | monocyte differentiation | |
Biological Process | response to amphetamine | |
Biological Process | serotonin metabolic process | |
Biological Process | signal transduction | |
Biological Process | visual learning |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A384D762
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 134-491 | PDEase | ||||
Sequence: VGPTYSTVVLNCLKNLDLWCFDVFSLNRAADDHALRTIVFELLTRHNLISRFKIPTVFLMTFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTRDEFVELRALVIEMVLATDMSCHFQQVKCMKTALQQLERIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLVDEDSKSKTQPSFQWRQPSLDVEVGDPNPDVVSFRSTWTKYIQENKQKWKERAASG | ||||||
Region | 484-524 | Disordered | ||||
Sequence: WKERAASGVTNQMSIDELSPCEEEALPSPAEDEHNQNGNLD |
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length524
- Mass (Da)60,193
- Last updated2018-11-07 v1
- ChecksumA8806765A055CCC4
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A384D7I3 | A0A384D7I3_URSMA | PDE1B | 527 | ||
A0A384D774 | A0A384D774_URSMA | PDE1B | 519 | ||
A0A384D812 | A0A384D812_URSMA | PDE1B | 516 | ||
A0A384D824 | A0A384D824_URSMA | PDE1B | 479 |
Keywords
- Technical term